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>   home   >   Products   >   Primary Antibodies   >   Anti-Canine CD21 Antibody, clone CA2.1D6    

Anti-Canine CD21 Antibody, clone CA2.1D6 (RPE)

Mouse Anti-Dog Monoclonal Antibody

  • FC - Anti-Canine CD21 Antibody, clone CA2.1D6 (RPE) ABD12116
    Staining of canine peripheral blood lymphocytes with Mouse anti Canine CD21:RPE
  • FC - Anti-Canine CD21 Antibody, clone CA2.1D6 (RPE) ABD12116
    Staining of canine peripheral blood lymphocytes with Mouse anti Canine CD21:Alexa Fluor® 647
  • FC - Anti-Canine CD21 Antibody, clone CA2.1D6 (RPE) ABD12116
    Staining of canine peripheral blood lymphocytes with Mouse anti Canine CD21
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Dog
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names CA2.1D6
Additional Information
Other Species Hs,Cat,Raccoon
Purification Purified IgG prepared by affinity chromatography on Protein A
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Canine CD21 antibody, clone CA2.1D6 recognizes canine CD21, also known as Complement receptor type 2. CD21 is a cell surface antigen expressed by canine B lymphocytes.The antigen recognised may be the canine homologue of human CD21, but this has not been fully confirmed.Mouse anti-Canine CD21 antibody , clone CA2.1D6 also recognizes the CD21 antigen in Felids. Expression in cats is analogous to that seen in dogs with strong expression on lymphocytes, in a manner mutually exclusive with expression of CD4 or CD8. Clone CA2.1D6 also immunoprecipitates a 145kDa protein from feline lymphocytes, similar to the protein immunoprecipitated by the antibody from canine lymphocytes (Deanet al.1996).
Preservative & Stabilisers 0.09% Sodium azide; Stabilising agent
Storage Storage at +4ºC. DO NOT FREEZE.
PrecautionsAnti-Canine CD21 Antibody, clone CA2.1D6 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Cobbold, S. & Metcalfe, S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW).
Tissue Antigens. 43 (3): 137-54. 2. Brodersen, R. et al. (1998) Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various CD markers of human and 11 animal species.
Vet. Immunol. Immunopathol. 64: 1-13. 3. Dean, G.A. et al. (1996) Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node.
J Virol. 70 (8): 5165-9. 4. Faldyna, M. et al. (2004) Lymphocyte subsets in synovial fluid from clinically healthy joints of dogs.
Acta Vet. Brno 73: 73-8. 5. Bund, D. et al. (2010) Canine-DCs using different serum-free methods as an approach to provide an animal-model for immunotherapeutic strategies.
Cell Immunol. 263: 88-98. 6. Huang, Y.C. et al. (2008) CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells.
J Leukoc Biol. 84: 1501-10. 7. Mortarino, M. et al. (2009) ZAP-70 and Syk expression in canine lymphoid cells and preliminary results on leukaemia cases.
Vet Immunol Immunopathol. 128: 395-401. 8. Reggeti, F. et al. (2008) CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.
J Gen Virol. 89: 277-87. 9. Wang, Y.S. et al. (2007) Characterization of canine monocyte-derived dendritic cells with phenotypic and functional differentiation.
Can J Vet Res. 71: 165-74. 10. Lankford, S. et al. (2008) Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells.
Vet Immunol Immunopathol. 122: 159-66. 11. Araujo, M.S. et al. (2011) Immunological changes in canine peripheral blood leukocytes triggered by immunization with first or second generation vaccines against canine visceral leishmaniasis.
Vet Immunol Immunopathol. 141: 64-75. 12. Estrela-Lima, A. et al. (2010) Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates.
BMC Cancer. 10: 256. 13. Horn, P.A. et al. (2004) Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol.
Blood. 103: 3710-6. 14. Hsiao, Y.W. et al. (2004) Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity.
J Immunol. 172: 1508-14. 15. Jubala, C.M. et al. (2005) CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma.
Vet Pathol. 42: 468-76. 16. Gaurnier-Hausser, A. et al. (2011) NEMO-Binding Domain Peptide Inhibits Constitutive NF-{kappa}B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma.
Clin Cancer Res. 17: 4661-71. 17. Maiolini, A. et al. (2012) Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis.
J Neuroinflammation. 9: 226. 18. Cave, N.J. et al. (2012) Systemic effects of periodontal disease in cats.
Vet Q. 32: 131-44. 19. Yuasa, K. et al. (2007) Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products.
Gene Ther. 14: 1249-60. 20. Aresu, L. et al. (2014) VEGF and MMP-9: biomarkers for canine lymphoma.
Vet Comp Oncol. 12: 29-36. 21. Heinrich, F. et al. (2015) Immunophenotyping of immune cell populations in the raccoon (Procyon lotor)
Vet Immunol Immunopathol. Nov 3 [Epub ahead of print]

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Cat# ABD12116
(40 western blots)
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