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Anti-Human EGF Receptor Antibody, clone ICR10

Rat Anti-Human Monoclonal Antibody

  • FC - Anti-Human EGF Receptor Antibody, clone ICR10  ABD12118
    Staining of A431 cells with Rat anti Human EGF Receptor:FITC
  • FC - Anti-Human EGF Receptor Antibody, clone ICR10  ABD12118
    Staining of A431 cells with Rat anti Human EGF Receptor
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00533
Reactivity Human
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names ICR10
Calculated MW 134277 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Extracellular domain of human EGF-receptor from head and neck carcinoma.
Shelf Life 12 months from date of reconstitution.
Gene ID 1956
Other Names Epidermal growth factor receptor,, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Target/Specificity Rat anti-Human EGF Receptor antibody, clone ICR10 recognizes the human epidermal growth factor receptor (EGF-R), which is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas.High level expression of EGFR is often associated with advanced disease and poor prognosis.Rat anti-Human EGF Receptor antibody, clone ICR10 binds to epitope B from EGFR (Lottazet al.2010andModjtahediet al.1993) and has an affinity of 6.7 x 10-9M.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human EGF Receptor Antibody, clone ICR10 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Lottaz,C. et al. (2010) Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin
Cancer Res. 70: 2030-40. 2. Modjtahedi, H. et al. (1993) Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor.
Cell Biophys. 1993. 22 (1-3): 129-146. 3. Modjtahedi, H. et al. (2012) Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.
Br J Cancer. 106: 883-888 4. Grinberg, O. et al. (2013) Antibody modified Bovine Serum Albumin microspheres for targeted delivery of anticancer agent Gemcitabine
Polymers for Advanced Technologies. 24 (3): 294-299. 5. Gilcrease, M.Z. et al. (2009) Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer.
J Exp Clin Cancer Res. 28: 67. 6. Lottaz, C. et al. (2010) Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of origin.
Cancer Res. 70: 2030-40. 7. Tilburgs, T. et al. (2015) Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.
Proc Natl Acad Sci U S A. 112 (23): 7219-24.

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Cat# ABD12118
(40 western blots)
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