|Application ||IHC-P, FC, IP|
|Calculated MW||40983 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||T-end.1, a pMT transformed endothelial cell line|
|Shelf Life||18 months from date of despatch.|
|Other Names||Hematopoietic progenitor cell antigen CD34, CD34, Cd34|
|Target/Specificity||Rat anti-Mouse CD34 antibody, clone MEC14.7 recognizes the murine CD34 cell surface antigen, which is expressed by endothelial cells and by haematopoietic stem cells. This antibody recognizes a neuraminidase sensitive epitope. As in the human system, CD34 antibodies in the mouse demonstrate slightly different staining patterns depending on their fine specificity. Rat anti-Mouse CD34 antibody, clone MEC14.7 appears to recognize a subset of the stem cell population recognized by clone RAM34, and it is thought that this is due to differences in the epitope recognized by the two antibodies.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD34 Antibody, clone MEC14.7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Garlanda, C. et al. (1997) Characterization of MEC14.7, a new monoclonal antibody recognising mouse CD34: a useful reagent for identifying and characterizing blood vessels and haematopoietic precursors.Eur. J. Cell Biol. 73: 368-377. 2. Winding, B. et al. (2002) Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.Clin. Cancer Res. 8: 1932-1939. 3. Morison, N.B. et al. (2007) The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-onlycontraceptives in women.Reproduction. 133: 309-21. 4. Chen, L. et al. (2010) Roles of tetrahydrobiopterin in promoting tumor angiogenesis.Am J Pathol. 177: 2671-80. 5. Ager, E.I. et al. (2010) Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.Cancer Cell Int. 10: 19 6. Chabot, S. et al. (2011) A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor.J Exp Med. 208: 973-86. 7. Chen, J. et al. (2011) Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage.Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E62-71. 8. Chen, J. et al. (2012) Transfusion of CXCR4-Primed Endothelial Progenitor Cells Reduces Cerebral Ischemic Damage and Promotes Repair in db/db Diabetic Mice.PLoS ONE 7(11): e50105.
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