|Application ||IHC-F, IF, FC, IP|
|Calculated MW||128770 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A|
|Target/Specificity||Mouse anti-Human CD11a antibody, clone 38 recognizes the integrin alphaL subunit, a 180 kDa glycoprotein expressed by all human leucocytes. CD11a is involved in cell-cell adhesion processes and binds to ICAM-1, 2 and 3.Mouse anti-Human CD11a antibody, clone 38 neutralizes CD11a mediated adhesion.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD11a Antibody, clone 38 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Dransfield, I. & Hogg, N. (1989) Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.EMBO J. 8 (12): 3759-65. 1. Daehn, I.S. (2010) T-lymphocyte-induced, fas-mediated apoptosis is associated with early keratinocyte differentiation.Exp Dermatol. 19: 372-80. 2. Berg, L.P. et al. (2002) Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium.J Immunol. 168 (7): 3227-34. 3. Foster, G.R. et al. (2004) IFN-alpha subtypes differentially affect human T cell motility.J Immunol. 173: 1663-70. 4. Evans, B.J. et al. (2006) Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.Blood. 107: 3593-9. 5. Suchard, S.J. et al. (2010) An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.J Immunol. 184: 3917-26. 6. Porter, J.C. and Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.FASEB J. 23: 492-502.
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