|Application ||WB, IHC-P, IHC-F, FC, E, IP|
|Calculated MW||28295 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Shelf Life||18 months from date of despatch.|
|Other Names||CD151 antigen, GP27, Membrane glycoprotein SFA-1, Platelet-endothelial tetraspan antigen 3, PETA-3, Tetraspanin-24, Tspan-24, CD151, CD151, TSPAN24|
|Target/Specificity||Mouse anti-Human CD151 antibody, clone 11G5a recognizes the human CD151 cell surface antigen, also known as PETA-3. CD151 is expressed by epithelial cells, endothelial cells, platelets, megakaryocytes, monocytes and in the renal glomeruli and proximal and distal tubules. CD151 is not expressed by lymphocytes or granulocytes. More recently CD151 has also been shown to be expressed by erythrocytes, and to carry the MER2 blood group antigen (Crewet al.2004).It should be noted that CD151 is very closely associated with the alpha3 beta1 integrin in cells and co-immunoprecipitation may occur even in quite stringent conditions (Yauch.et al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD151 Antibody, clone 11G5a is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Yauch, R.L. et al. (1998) Highly stoichiometric, stable, and specific association of integrin alpha 3 beta 1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration.Mol. Cell. Biol. 9: 2751-2765. 2. Crew, V.K. et al. (2004) CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104:2217-2223. 3. Zheng, Z. and Liu, Z. (2006) CD151 gene delivery activates PI3K/Akt pathway and promotes neovascularizationafter myocardial infarction in rats.Mol Med. 12: 214-220. 4. Zheng, Z.Z. and Liu, Z.X. (2007) CD151 gene delivery increases eNOS activity and induces ECV304 migration,proliferation and tube formation.Acta Pharmacol Sin. 28: 66-72. 5. Franco M et al. (2010) The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.J Biol Chem. 285 (50): 38756-64. 6. Hasegawa, M. et al. (2007) CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity.Lab Invest. 87: 882-92. 7. Spoden, G. et al. (2008) Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).PLoS One. 3: e3313. 8. Huang, X.Y. et al. (2010) Overexpression of CD151 as an adverse marker for intrahepatic cholangiocarcinoma patients.Cancer. 116: 5440-51. 9. Ke, A.W. et al. (2009) Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.Hepatology. 49: 491-503. 10. Devbhandari, R.P. et al. (2011) Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin ß1 complex in the progression of hepatocellular carcinoma.PLoS One. 6: e24901. 11. Shi, G.M. et al. (2010) CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma.Hepatology. 52: 183-96. 12. Nishiuchi, R. et al. (2005) Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151.Proc Natl Acad Sci U S A.102: 1939-44. 13. Ke, A.W. et al. (2011) CD151 amplifies signaling by integrin a6ß1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells.Gastroenterology. 140: 1629-41.e15.1. Kwon, M.J. et al. (2012) Clinical significance of CD151 overexpression in subtypes of invasive breast cancer.Br J Cancer. 106: 923-30.
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