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Anti-Human CDw108 Antibody, clone MEM-150

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti-Human CDw108 Antibody, clone MEM-150  ABD12134
    Published customer imageAttempts to block the MTRAP-Semaphorin-7A interaction has no effect on erythrocyte invasion. (A) Recombinant Semaphorin-7A and MTRAP have no inhibitory effect on erythrocyte invasion. Purified pentamerised Semaphorin-7A or MTRAP were added to P. falciparum erythrocyte invasion assays at concentrations that exceeded the monomeric equilibrium affinity constant by a factor of 10. (B) Monoclonal anti-Semaphorin-7A antibody has no effect on erythrocyte invasion. Monoclonal anti-Semaphorin-7A (MEM-150) and an anti-basigin positive control (MEM-M6/6) were added to P. falciparum erythrocyte invasion assays in increasing concentrations. MEM-M6/6 showed clear inhibition of invasion, whereas MEM-150 had no observable effect. (C) Rabbit polyclonal antibodies against purified monomeric MTRAP and Semaphorin-7A bind native MTRAP and Semaphorin-7A. Erythrocyte ghosts (left blot) and parasite supernatants (right blot) were analysed by Western blot under non-reducing conditions, and detected by incubation with purified polyclonal antibodies, followed by an anti-rabbit-IgG-HRP antibody. The predicted monomer molecular weights of native Semaphorin-7A and MTRAP are 79.3 and 55.6 kDa respectively. The top arrow indicates the dimer and the bottom arrow the monomer of Semaphorin-7A. (D) Polyclonal antibodies against MTRAP and Semaphorin-7A do not inhibit erythrocyte invasion. Purified polyclonal antibodies against MTRAP and Semaphorin-7A were added to P. falciparum erythrocyte invasion assays but did not affect the efficiency of invasion relative to a positive control (anti-AMA-1).From: Bartholdson SJ, Bustamante LY, Crosnier C, Johnson S, Lea S, et al. Semaphorin-7A Is an Erythrocyte Receptor for P. falciparum Merozoite-Specific TRAP Homolog, MTRAP. PLoS Pathog 8: e1003031.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75326
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names MEM-150
Calculated MW 74824 Da
Additional Information
Purification Purified IgM prepared by ion exchange chromatography
Shelf Life 18 months from date of despatch.
Gene ID 8482
Other Names Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD108, SEMA7A, CD108, SEMAL
Target/Specificity Mouse anti-Human CDw108 antibody, clone MEM-150 recognizes the human CDw108, cell surface antigen, also known as Semaphorin-7A, John-Milton-Hargen human blood group Ag, Semaphorin-K1 or Semaphorin-L. CDw108 is a 666 amino acid ~80 kDa GPI linked glycoprotein containing a single Ig-like C2 type domain and a single SEMAdomain.CDw108 is expressed by erythrocytes, some T cell lines and some activated lymphocytes.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CDw108 Antibody, clone MEM-150 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Mudad, R. et al. (1995) Evidence that CDw108 membrane protein bears the JMH blood group antigen.
Transfusion. 35: 566-70. 2. Bartholdson, S.J. et al. (2012) Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.
PLoS Pathog. 8: e1003031.

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Cat# ABD12134
(40 western blots)
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