|Application ||WB, FC, IP|
|Calculated MW||71801 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Purified CD6 antigen|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell differentiation antigen CD6, T12, TP120, CD6, CD6|
|Target/Specificity||Mouse anti-Human CD6 antibody, clone MEM-98 recognizes human CD6, also known as T12 or TP120. CD6 is a ~100-130 kDa type 1 single pass trans-membrane protein member of the immunoglobulin superfamily. CD6 possesses 3 scavenger receptor cysteine rich (SRCR) domains in it’s extracellular sequence. The membrane proximal SRCR3 contains the epitope responsible for interaction with CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166. Multiple gene transcripts have been detected encoding CD6 in man resulting in the production of a number of CD6 isoforms. Mouse anti-human CD6, clone MEM-98 recognizes an external epitope located in the membrane-distal SRCR domain 1 and is expected to recognize all CD6 isoforms so far identified, CD6A-E.CD6 has been implicated as a therapeutic target for a number of autoimmune conditions (Pintoet al.2013) including Sjögren's syndrome (Ramos-Casalset al.2001) , rheumatoid arthritis (Rodriguezet al.) and psoriasis (Wilsmann-Theiset al.2006).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD6 Antibody, clone MEM-98 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Bazil, V. et al. (1989) Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102.Folia Biol (Praha). 35 (5): 289-97. 2. Nair, P. et al. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction.Clin Exp Immunol. 162: 116-30. 3. Castro, M.A. et al. (2007) Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.J Immunol. 178: 4351-61. 4. Hassan, N.J. et al. (2006) CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.Mol Cell Biol. 26: 6727-38.
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