|Calculated MW||55093 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, CD172a, SIRPA, MYD1, PTPNS1, SHPS1, SIRP|
|Target/Specificity||Mouse anti-Bovine CD172a antibody, clone CC149 recognizes bovine CD172a, also known as MyD-1 antigen and SIRPA. CD172a is a ~55 kDa single pass type 1 membrane protein belonging to the family of signal regulatory proteins (SIRP). CD172a has been identified as the receptor for CD47.Bovine CD172a is strongly expressed by splenic macrophages, monocytes and a subset of afferent lymph veiled cells (ALVC) and by dendritic cells in the skin.|
|Preservative & Stabilisers||0.09% Sodium Azide; Stabilizing agent|
|Storage||Storage at +4ºC. DO NOT FREEZE.|
|Precautions||Anti-Bovine CD172a Antibody, clone CC149 (RPE-CY5) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Howard, C.J. et al. (1999) Dendritic cells in cattle: phenotype and function.Vet Immunol Immunopathol. 72 (1-2): 119-24. 2. Price, S.J. & Hope, J.C.. (2009) Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals.Immunology. 126:201-8 3. Waters, W.R. (2009) Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria.PLoS One. 4: e6414. 4. Brackenbury, L.S. et al. (2005) Identification of a cell population that produces alpha/beta interferon in vitroandin vivo in response to noncytopathic bovine viral diarrhea virus.J Virol. 79: 7738-44. 5. Smith, R. et al. (2003) A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes.Blood.102:2532-40. 6. Jensen, K. et al. (2014) Comparison of small interfering RNA (siRNA) delivery into bovine monocyte-derived macrophages by transfection and electroporation.Vet Immunol Immunopathol. 158 : 224-32. 7. Tahoun, A. et al. (2015) Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella.Vet Res. 46: 9. 8. Hussen J et al. (2014) The chemokine CCL5 induces selective migration of bovine classical monocytes and drives their differentiation into LPS-hyporesponsive macrophages in vitro.Dev Comp Immunol. 47 (2): 169-77. 9. Eger, M. et al. (2015) Impacts of parturition and body condition score on glucose uptake capacity of bovine monocyte subsets.Vet Immunol Immunopathol. 166 (1-2): 33-42. 10. Vachiery N et al. (2015) An in vitro model to assess the immunosuppressive effect of tick saliva on the mobilization of inflammatory monocyte-derived cells.Vet Res. 46 (1): 117.
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