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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD177 Antibody, clone MEM-166 (RPE)   

Anti-Human CD177 Antibody, clone MEM-166

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD177 Antibody, clone MEM-166  ABD12149
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD56:Alexa Fluor® 647
  • FC - Anti-Human CD177 Antibody, clone MEM-166  ABD12149
    Staining of human peripheral blood granulocytes with Mouse anti Human CD177:FITC
  • FC - Anti-Human CD177 Antibody, clone MEM-166  ABD12149
    Staining of human peripheral blood granulocytes with Mouse anti Human CD177:RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N6Q3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MEM-166
Calculated MW 46363 Da
Additional Information
Other Species Rh
Purification Purified IgG prepared by affinity chromatography on Protein G.
Shelf Life 18 months from date of despatch.
Gene ID 57126
Other Names CD177 antigen, Human neutrophil alloantigen 2a, HNA-2a, NB1 glycoprotein, NB1 GP, Polycythemia rubra vera protein 1, PRV-1, CD177, CD177, NB1, PRV1
Target/Specificity Mouse anti-Human CD177 antibody, clone MEM-166 recognizes human CD177 (neutrophil glycoprotein NB1). The neutrophil NB1 antigen is expressed by 97% of the caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD177 Antibody, clone MEM-166 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Caruccio, L. et al. (2003) Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy.
Transfusion. 43 (3): 357-63. 2. Kissel, K. et al. (2002) Molecular basis of NB1 (HNA-2a, CD177) deficiency.
Blood. 99 (11): 4231-3. 3. Jerke, U. et al. (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.
J Biol Chem. 286 (9): 7070-81. 4. Dillon, M. et al. (2008) Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines.
Leuk Res. 32: 811-9. 5. Gabillet, J. et al. (2012) Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
J Immunol. 189: 2574-83. 6. Drewniak, A. et al. (2008) Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes.
Haematologica. 93:1058-67. 7. Drewniak, A. et al. (2009) Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes.
Blood. 113: 5979-98. 8. Sachs, .U.J. et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).
J Biol Chem. 282: 23603-12.

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Cat# ABD12149
(40 western blots)
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