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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human CD222 Antibody, clone MEM-238 (FITC)   

Anti-Human CD222 Antibody, clone MEM-238

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human CD222 Antibody, clone MEM-238  ABD12152
    Staining of permeablised human peripheral blood monocytes with Mouse anti Human CD222:FITC
  • FC - Anti-Human CD222 Antibody, clone MEM-238  ABD12152
    Staining of permeablised human peripheral blood granulocytes with Mouse anti Human CD222
  • FC - Anti-Human CD222 Antibody, clone MEM-238  ABD12152
    Staining of permeablised human peripheral blood granulocytes with Mouse anti Human CD222:APC
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P11717
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MEM-238
Calculated MW 274375 Da
Additional Information
Other Species Rh
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen Recombinant vaccinia virus containing CD222.
Shelf Life 18 months from date of despatch.
Gene ID 3482
Other Names Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, CD222, IGF2R, MPRI
Target/Specificity Mouse anti-Human CD222 antibody, clone MEM-238 recognizes human CD222, a 250 kDa transmembrane protein originally identified as the IGF II receptor. CD222 is ubiquitously expressed and is involved with internalization of a variety of ligands.Mouse anti-Human CD222 antibody, clone MEM-238 recognizes an epitope located in the region between extracellular domains 2 and 5 (aa 192-697) of CD222 (Robertset al.2010).CD222 is primarily expressed intracellularly with a small percentage of molecules being located at the cell surface (5 - 10%).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human CD222 Antibody, clone MEM-238 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Roberts, R.C. et al. (2010) Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C.
Hum Mol Genet. 19: 1009-18. 2. Adachi, A. et al. (2010) Golgi-associated GSK3beta regulates the sorting process of post-Golgi membrane trafficking.
J Cell Sci. 123: 3215-25. 3. Godar, S. et al. (2002) CD222 (Mannose-6 phosphate / insulin-like growth factor II-receptor) Summary and Workshop Report.
In Leucocyte Typing VII: White Cell Differentiation Antigens. Edited by Mason, D. et al. Oxford University Press. pp482-485. 4. Rezgui, D. et al. (2009) Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.
J Mol Endocrinol. 42: 341-56. 5. McCormick, P.J. et al. (2008) Palmitoylation controls recycling in lysosomal sorting and trafficking.
Traffic. 9: 1984-97. 6. Leksa, V. et al. (2002) The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration.
J Biol Chem. 277 (43): 40575-82. 7. Osborne, D.G. et al. (2015) Monitoring receptor trafficking following retromer and WASH deregulation.
Methods Cell Biol. 130: 199-213.

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Cat# ABD12152
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