|Application ||IHC-F, FC, E, IP|
|Calculated MW||149715 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G.|
|Immunogen||Human lung CD143 (Angiotensin converting enzyme)|
|Shelf Life||18 months from date of despatch.|
|Other Names||Angiotensin-converting enzyme, ACE, 3.2.1.-, 188.8.131.52, Dipeptidyl carboxypeptidase I, Kininase II, CD143, Angiotensin-converting enzyme, soluble form, ACE, DCP, DCP1|
|Target/Specificity||Mouse anti-Human CD143 antibody, clone 9B9 recognizes human somatic CD143, also know as angiotensin - converting enzyme (ACE). CD143 exists in two forms, a ~170 kDa somatic form and a ~90 kDa germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.This antibody recognizes active ACE binding to an N-terminal domain epitope, different to that recognized by clone i2H5 (MCA2055).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD143 Antibody, clone 9B9 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Danilov, S. et al. (1994) Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site.J Biol Chem. 269 (43): 26806-14. 2. Metzger, R. et al. (2000) CD143 in the development of atherosclerosis.Atherosclerosis. 150 (1): 21-31. 3. Danilov, S.M. et al. (1991) Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme.Lab Invest. 64 (1): 118-24. 4. Ulrich, C. et al. (2011) Monocyte Angiotensin converting enzyme expression may be associated with atherosclerosis rather than arteriosclerosis in hemodialysis patients.Clin J Am Soc Nephrol. 6: 505-11. 5. Danilov, S. et al. (1989) Radioimmunoimaging of lung vessels: an approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme.J Nucl Med. 30:1686-92. 6. Atochina, E. et al. (1998) Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress.Am J Physiol. 275:L806-17.
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