|Application ||IHC-F, FC, IP|
|Calculated MW||115696 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Lymphoma cell line TK1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, Lymphocyte Peyer patch adhesion molecules subunit alpha, LPAM subunit alpha, VLA-4 subunit alpha, CD49d, Itga4|
|Target/Specificity||Rat anti-Mouse CD49d monoclonal antibody, clone R1-2 recognizes murine CD49d, an integrin, also known as integrin alpha-4 or very late antigen 4 alpha subunit. CD49d forms a heterodimer at the cell surface with CD29 to form VLA-4, and is involved in cell-cell and cell-extracellular matrix interactions.Clone R1-2 recognises an epitope within residues 195-268 of CD49d, designated as B1 (Kamadaet al.1995).Rat anti-Mouse CD49d, clone R1-2 has been reported to inhibit the adhesion of murine lymphocytes to Peyer's patch HEV, (Holzmannet al.1989)) and prevent central nervous system inflammation and experimental encephalomyelitis by inhibiting recruitment of inflammatory leukocytes (Brockeet al.1999).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD49d Antibody, clone R1-2 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kamata, T. et al. (1995) Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)Biochem J. 305 ( Pt 3): 945-51. 2. Holzmann, B. & Weissman, I.L. (1989) Integrin molecules involved in lymphocyte homing to Peyer's patches.Immunol Rev. 108: 45-61. 3. Chiesa, S. et al. (2011) Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells.Proc Natl Acad Sci U S A. 108 (42): 17384-9.
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