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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148    

Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148  ABD12159
    Staining of human peripheral blood monocytes with Mouse anti Human CD18 (Activation Epitope):Biotin
  • FC - Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148  ABD12159
    Staining of human peripheral blood monocytes with Mouse anti Human CD86 (Activation Epitope): Azide free
  • FC - Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148  ABD12159
    Staining of human peripheral blood granulocytes with Mouse anti Human CD18 (ACT EPITOPE)
  • FC - Anti-Human CD18 (Activation Epitope) Antibody, clone MEM-148  ABD12159
    Staining of human peripheral blood granulocytes with Mouse anti Human CD18 (Activation Epitope):RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05107
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MEM-148
Calculated MW 84782 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Peripheral blood mononuclear cells.
Shelf Life 18 months from date of despatch.
Gene ID 3689
Other Names Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Target/Specificity Mouse anti-Human CD18 (Activation Epitope) antibody, clone MEM-148 recognizes an epitope on the human CD18 molecule that is hidden in the CD11/CD18 heterodimer on resting cells. Clone MEM-148 binds very weakly to resting peripheral blood leukocytes and strongly to all leukocytes upon cellular activation. The epitope recognized by Mouse anti-Human CD18 (Activation Epitope) antibody, clone MEM-148 is also exposed during dissociation of the CD11/CD18 by low pH.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD18 (Activation Epitope) Antibody, clone MEM-148 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Drbal, K. et al. (2001) A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells.
Blood. 98: 1561-1566. 2. Luissint, al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
J. Cell. Biol. 183: 1159-1173. 3. Feng, C. et al. (2011) Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1.
J Leukoc Biol. 90: 313-21. 4. Anogianaki, A. et al. (2007) Capsaicin an irritant anti-inflammatory compound.
J Biol Regul Homeost Agents. 21: 1-4. 5. Arthos, J. et al. (2008) HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
Nat Immunol. 9: 301-9. 6. Cairo, C.W. et al. (2006) Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering.
Immunity. 25: 297-308. 7. Tang, X.Y. et al. (2008) Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece.
J Immunol. 180: 4793-804. 8. Kudlová M. et al. (2007) Expression of an activated form of integrin beta2 chain CD18 in cardiac surgical operations.
Acta Medica (Hradec Kralove). 50: 187-93. 9. Solovjov, D.A. et al. (2005) Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2.
J Biol Chem. 280: 1336-45. 10. Ehirchiou, D. et al. (2005) Dual function for a unique site within the beta2I domain of integrin alphaMbeta2.
J Biol Chem. 280: 8324-31. 11. Cheng, M. et al. (2007) Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.
J Biol Chem. 282: 18225-32. 12. Shi, M. et al. (2007) A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins.
J Biol Chem. 282: 30198-206.

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Cat# ABD12159
(40 western blots)
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