|Application ||IHC-F, FC, IP|
|Calculated MW||127829 Da|
|Other Species||Cynomolgus Pr|
|Purification||Purified IgG prepared from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD11c, ITGAX, CD11C|
|Target/Specificity||Mouse anti-Human CD11c antibody, clone Bu15 recognizes the integrin alphax subunit (ITGAX), a 150 kDa glycoprotein also known as CD11 antigen-like family member C or Leu M5, CD11c is expressed by macrophages, monocytes, NK cells and most dendritic cells (Kohrgruberet al.1999). CD11c is also expressed at a lower level by granulocytes. CD11c forms a heterodimeric integral membrane protein with the integrin beta 2 chain to form the leukocyte specific integrin 'inactivated-C3b receptor 4'. CD11c interacts with a number of ligands including the G-P-R sequence in fibrinogen, ICAM-1 (Fricket al.2005), iC3b (Sadhuet al.2007) and Junctional adhesion molecule-like (Bazzoniet al.2011). CD11c is involved in cell-cell interactions during the inflammatory process and is important for monocyte adhesion and chemotaxis. CD11c also acts as a signalling receptor for polysaccharide (Inquallset al.1995)CD11c is expressed by hairy cell leukaemia cells (Goodmanet al.2003;Nicolaouet al.2003).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD11c Antibody, clone BU15 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Hogg, N. et al. (1986) The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.Eur J Immunol. 16 (3): 240-8. 2. Loike, J.D. et al. (1991) CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen.Proc Natl Acad Sci U S A. 88 (3): 1044-8. 3. Newman, K.C. et al. (2006) Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria.PLoS Pathog. 2: e118. 4. Sanchez-Madrid, F. and Corbi, A.L. (1992) Leukocyte integrins: structure, function and regulation of their activity.Seminars Cell Biol. 3: 199-210. 5. Silk, K.M. et al. (2012) Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.J Biomed Biotechnol. 2012:172420. 6. Bird, R.C. et al. (2011) An autologous dendritic cell canine mammary tumor hybrid-cell fusion vaccine.Cancer Immunol Immunother. 60 (1): 87-97. 7. Eisenhardt, S.U. et al. (2007) Generation of activation-specific human anti-alphaMbeta2 single-chain antibodies as potential diagnostic tools and therapeutic agents.Blood. 109: 3521-8. 8. Herman, S. et al. (2012) Regulatory T cells form stable and long-lasting cell cluster with myeloid dendritic cells (DC).Int Immunol. 24 (7): 417-26. 9. Levy, O. et al. (2003) Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release.Infect Immun. 71: 6344-53. 10. Xie, Z. et al. (2015) Human umbilical cord-derived mesenchymal stem cells elicit macrophages into an anti-inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats.Stem Cells. Nov 2. [Epub ahead of print] 11. Brown, D.P. et al. (2009) The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonellainfection.BMC Immunol. 10: 56.1. Larson, R.S. & Springer, T.A. (1990) Structure and function of leukocyte integrins.Immunol Rev. 114: 181-217.
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