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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human HLA A2 Antibody, clone BB7.2 (RPE)   

Anti-Human HLA A2 Antibody, clone BB7.2

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human HLA A2 Antibody, clone BB7.2  ABD12162
    Staining of human peripheral blood lymphocytes with Mouse anti Human HLA-A2
  • FC - Anti-Human HLA A2 Antibody, clone BB7.2  ABD12162
    Staining of human peripheral blood monocytes with Mouse anti Human HLA-A2:Alexa Fluor® 488
  • FC - Anti-Human HLA A2 Antibody, clone BB7.2  ABD12162
    Staining of human peripheral blood lymphocytes with Mouse anti Human HLA-A2: endotoxin low
  • FC - Anti-Human HLA A2 Antibody, clone BB7.2  ABD12162
    Staining of human peripheral blood monocytes with Mouse anti Human HLA-A2:FITC
  • FC - Anti-Human HLA A2 Antibody, clone BB7.2  ABD12162
    Staining of human peripheral blood lymphocytes with Mouse anti Human HLA-A2: RPE
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, FC, IP
Primary Accession P01892
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names BB7.2
Calculated MW 40922 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.
Immunogen Papain solubilised HLA-A2
Shelf Life 18 months from date of despatch.
Other Names HLA class I histocompatibility antigen, A-2 alpha chain, MHC class I antigen A*2, HLA-A, HLAA
Target/Specificity Mouse anti-Human HLA A2 antibody, clone BB7.2 recognizes the human HLA-A2 histocompatability antigen. The epitope recognized by this antibody has been studied extensively and would appear to include the carboxy-terminus of the alpha-2 helix and a turn on one of the underlying beta strands. Mouse anti-Human HLA A2 antibody, clone BB7.2 may be used for the flow cytometric detection of HLA-A2 expression and has also been used for immunoaffinity purification of HLA-A2 molecules. Functionally Mouse anti-Human HLA A2 antibody, clone BB7.2 is reported to inhibit MHC restricted cellular cytotoxicity..
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human HLA A2 Antibody, clone BB7.2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Parham, P. & Brodsky, F.M. (1981) Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28.
Hum Immunol. 3 (4): 277-99. 2. Hogan, K.T. & Brown, S.L. (1992) Localization and characterization of serologic epitopes on HLA-A2.
Hum Immunol. 33 (3): 185-92. 3. Harig, S. et al. (2001) Induction of cytotoxic T-cell responses against immunoglobulin V region-derived peptides modified at human leukocyte antigen-A2 binding residues.
Blood. 98 (10): 2999-3005. 4. Pantenburg, B. et al. (2010) Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells.
Am J Trop Med Hyg. 82:600-7. 5. Duncan, L.M. et al. (2010) Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression.
J Immunol. 184: 6978-85. 6. Wang, B. et al. (2004) Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein.
Blood. 104: 200-6. 7. Wooldridge, L. et al. (2007) Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
Eur J Immunol. 37: 1323-33. 8. Wooldridge, L. et al. (2010) MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
J Immunol. 184: 3357-66. 9. Popovic, J. et al. (2011) The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.
Blood. 118 (4): 946-54. 10. Schmidt, J. et al. (2011) Reversible Major Histocompatibility Complex I-Peptide Multimers Containing Ni2+-Nitrilotriacetic Acid Peptides and Histidine Tags Improve Analysis and Sorting of CD8+ T Cells.
J Biol Chem. 286: 41723-35.

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Cat# ABD12162
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