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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD46 Antibody, clone MEM-258 (RPE)   

Anti-Human CD46 Antibody, clone MEM-258

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD46 Antibody, clone MEM-258  ABD12167
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46:RPE
  • FC - Anti-Human CD46 Antibody, clone MEM-258  ABD12167
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46
  • FC - Anti-Human CD46 Antibody, clone MEM-258  ABD12167
    Staining of human peripheral blood granulocytes with Mouse anti Human CD46: Alexa Fluor® 647
  • FC - Anti-Human CD46 Antibody, clone MEM-258  ABD12167
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, FC, IP, Func
Primary Accession P15529
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MEM-258
Calculated MW 43747 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen HPB-ALL cell line.
Shelf Life 12 months from date of reconstitution.
Gene ID 4179
Other Names Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10
Target/Specificity Mouse anti-Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP).CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD46 Antibody, clone MEM-258 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Sirena D et al. (2004) The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.
J Virol. 78 (9): 4454-62. 2. Fremeaux-Bacchi, V. et al. (2006) Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.
J Am Soc Nephrol. 17 (7): 2017-25. 3. Fleischli, C. et al. (2005) The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35.
J Virol. 79:10013-22. 4. Sweigard, J.H. et al. (2010) Adenovirus vectors targeting distinct cell types in the retina.
Invest Ophthalmol Vis Sci. 51:2219-28. 5. Yang, P. et al. (2009) Expression and modulation of RPE cell membrane complement regulatory proteins.
Invest Ophthalmol Vis Sci. 50: 3473-81. 6. Bahat, A. and Eisenbach, M. (2010) Human sperm thermotaxis is mediated by phospholipase C and inositol trisphosphate receptor Ca2+ channel.
Biol Reprod. 82: 606-16. 7. Bienaime, F. et al. (2010) Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome.
Kidney Int. 77: 339-49. 8. Wang, H. et al.(2008)In vitroandin vivo properties of adenovirus vectors with increased affinity to CD46.
J Virol. 82: 10567-79. 9. Hara, H. et al. (2011) Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs.
Invest Ophthalmol Vis Sci. 52: 5278-86. 10. El Karoui, K. et al. (2012) A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy.
J Am Soc Nephrol. 23 (1): 137-48. 11. Bach, P. et al. (2013) Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus.
Cancer Res. 73 (2): 865-74.

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Cat# ABD12167
(40 western blots)
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