|Application ||WB, IF, FC, IP, Func|
|Calculated MW||43747 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||HPB-ALL cell line.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10|
|Target/Specificity||Mouse anti-Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP).CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD46 Antibody, clone MEM-258 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Sirena D et al. (2004) The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3.J Virol. 78 (9): 4454-62. 2. Fremeaux-Bacchi, V. et al. (2006) Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.J Am Soc Nephrol. 17 (7): 2017-25. 3. Fleischli, C. et al. (2005) The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35.J Virol. 79:10013-22. 4. Sweigard, J.H. et al. (2010) Adenovirus vectors targeting distinct cell types in the retina. Invest Ophthalmol Vis Sci. 51:2219-28. 5. Yang, P. et al. (2009) Expression and modulation of RPE cell membrane complement regulatory proteins.Invest Ophthalmol Vis Sci. 50: 3473-81. 6. Bahat, A. and Eisenbach, M. (2010) Human sperm thermotaxis is mediated by phospholipase C and inositol trisphosphate receptor Ca2+ channel.Biol Reprod. 82: 606-16. 7. Bienaime, F. et al. (2010) Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome.Kidney Int. 77: 339-49. 8. Wang, H. et al.(2008)In vitroandin vivo properties of adenovirus vectors with increased affinity to CD46.J Virol. 82: 10567-79. 9. Hara, H. et al. (2011) Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs.Invest Ophthalmol Vis Sci. 52: 5278-86. 10. El Karoui, K. et al. (2012) A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy.J Am Soc Nephrol. 23 (1): 137-48. 11. Bach, P. et al. (2013) Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus.Cancer Res. 73 (2): 865-74.
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