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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Mouse CD49b Antibody, clone DX5 (FITC)   

Anti-Mouse CD49b Antibody, clone DX5

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD49b Antibody, clone DX5  ABD12171
    Splenocytes from a C57BL/6 SCID mouse double stained with Rat anti Mouse CD49b-FITC and MOUSE ANTI MOUSE NK1.1-R-PE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q62469
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgM
Clone Names DX5
Calculated MW 128955 Da
Additional Information
Purification Purified IgM from tissue culture supernatantPurified IgM from tissue culture supernatant
Immunogen RIL-2 propagated NK1.1+ cells from C57BL/6 mice.
Shelf Life 18 months from date of despatch.
Gene ID 16398
Other Names Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, Itga2
Target/Specificity Rat anti-Mouse CD49b monoclonal antibody, clone DX5 recognizes mouse CD49b, also known as Very Late Antigen-2 (VLA-2) or alpha-2 integrin. CD49b is a ~160kDa single pass type I membrane protein expressed by NK cells and a small subset of T-cells (Pellicciet al.2005).Rat anti-mouse CD49b, clone DX5 stains NK cells from all mouse strains tested including Balb/c mice (Areseet al.2001). CD49b acts as a receptor for collagen, laminin, fibronectin and E-cadherin (Carafoliet al.2013).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD49b Antibody, clone DX5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Arase, H. et al. (2001) Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).
J Immunol. 167 (3): 1141-4. 2. Leong, C.C. et al. (1998) Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog.
J Exp Med. 187 (10): 1681-7. 3. Yin, Y. et al. (2013) Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation.
Cancer Immunol Res. 1 (4): 256-68. 4. Lin, C.Y. et al. (2008) Combined immunogene therapy of IL-6 and IL-15 enhances anti-tumor activity through augmented NK cytotoxicity.
Cancer Lett. 272: 285-95. 5. Thomson, R.C. et al. (2008) Expansion and activation of NK cell populations in a gammaherpesvirus infection.
Scand J Immunol. 67: 489-95. 6. Pais, R. et al. (2012) An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes.
PLoS One. 7: e43182. 7. Jacobs, N. et al. (2006) Intradermal immune response after infection with Vaccinia virus.
J Gen Virol. 87: 1157-61.

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Cat# ABD12171
(40 western blots)
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