|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-chicken CD8 alpha, clone 11-39 recognizes the alpha chain of the chicken CD8 homologue, a 33-35kD cell surface protein. CD8 is expressed as either alpha/alpha homodimers or alpha/beta heterodimers on a subpopulation of T cells and NK cells. Mouse anti-chicken CD8 alpha, clone 11-39 recognises all polymorphic forms of chicken CD8 alpha. Mouse anti-chicken CD8 alpha, clone 11-39 has been demonstrated to cross react with Turkey (Liet al.1999).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||CD8 alpha Antibody, clone 11-39 (Monoclonal Antibody) (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Luhtala, M. et al. (1995) Characterization of chicken CD8-specific monoclonal antibodies recognizing novel epitopes.Scand J Immunol. 42 (1): 171-4. 2. Luhtala, M et al. (1997) Polymorphism of chicken CD8- alpha, but not CD8-beta. Immunogenetics. 46: 396 - 401. 3. Li, Z., et al (1999) Cross-Reactive Anti-Chicken CD4 and CD8 Monoclonal Antibodies Suggest Polymorphism of the Turkey CD8a MoleculePoultry Science 78:1526-1531 4. McKenna, G.F. (2003) Immunopathologic investigations with an attenuated chicken anemia virus in day-old chickens.Avian Dis. 47: 1339-45. 5. Morimura, T. et al. (1996) Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus.Arch Virol. 141 (11): 2243-9. 6. Luhtala M (1998) Chicken CD4, CD8alphabeta, and CD8alphaalpha T cell co-receptor molecules.Poult Sci. 77 (12): 1858-73. 7. Imhof, B.A. et al. (2000) Intestinal CD8 alpha alpha and CD8 alpha beta intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCR beta repertoires.J Immunol. 165 (12): 6716-22. 8. Arstila, T.P. & Lassila, O. (1993) Androgen-induced expression of the peripheral blood gamma delta T cell population in the chicken.J Immunol. 151 (12): 6627-33. 9. Bohls, R.L. et al. (2006) The use of flow cytometry to discriminate avian lymphocytes from contaminating thrombocytes.Dev Comp Immunol. 30 (9): 843-50. 10. Powell, F.L. et al. (2009) The turkey, compared to the chicken, fails to mount an effective early immune response to Histomonas meleagridis in the gut.Parasite Immunol. 31 (6): 312-27. 11. Katevuo, K & Vainio, O. (1996) Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery.Immunology. 89 (3): 419-23. 12. Morimura, T. et al. (1995) Immunomodulation of peripheral T cells in chickens infected with Marek's disease virus: involvement in immunosuppression.J Gen Virol. 76 ( Pt 12): 2979-85. 13. Powell, F. et al. (2009) Development of reagents to study the turkey's immune response: Identification and molecular cloning of turkey CD4, CD8α and CD28.Dev Comp Immunol. 33 (4): 540-6. 14. Juul-Madsen, H.R. et al. (2002) Major histocompatibility complex-linked immune response of young chickens vaccinated with an attenuated live infectious bursal disease virus vaccine followed by an infection.Poult Sci. 81 (5): 649-56. 15. Wang, Y. et al. (2003) A novel method to analyze viral antigen-specific cytolytic activity in the chicken utilizing flow cytometry.Vet Immunol Immunopathol. 95 (1-2): 1-9. 16. Arstila, T.P. et al. (1995) Primed avian γδ T cells respond to mycobacterial antigens, but show no preference for the 65-kDa heat shock protein.Cell Immunol. 162 (1): 74-9. 17. Arstila, T.P. et al. (1994) γδ and αβ T cells are equally susceptible to apoptosis.Scand J Immunol. 40 (2): 209-15. 18. Rosa, A.C. et al. (2014) Isolation and molecular characterization of Brazilian turkey reovirus from immunosuppressed young poults.Arch Virol. 159 (6): 1453-7.
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