|Application ||IHC-F, FC|
|Calculated MW||30154 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||CHO cells transfected with murine OX40|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134, Tnfrsf4, Ox40, Txgp1|
|Target/Specificity||Rat anti-Mouse CD134 antibody, clone OX-86 recognizes murine OX40 (CD134), a cell surface antigen expressed only by activated T lymphocytes.Rat anti-Mouse CD134 antibody, clone OX-86 is routinely tested on concanavalin A activated mouse splenocytes.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD134 Antibody, clone OX-86 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Higgins, L. M. et al. (1999) Regulation of T Cell Activation in vitroandin vivo by targeting the OX40-OX40 ligand interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, but not with an OX40 ligand-IgG fusion protein.J. Immunol. 162: 486-493. 3. Lavelle, E.C. et al. (2003) Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation.J Immunol. 171: 2384-92. 4. Lee, S.J. et al. (2004) 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.J Immunol. 173: 3002-12. 5. Maenz, M. et al. (2011) A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model.Mol Vis. 17: 420-9. 6. Zaini, J. et al. (2007) OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice.J Clin Invest. 117: 3330-8. 7. Andarini, S. et al. (2004) Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts.Cancer Res. 64: 3281-7. 8. Malmström, V. et al. (2001) CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.J Immunol. 166: 6972-81. 9. McHugh, R.S. et al. (2002) CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.Immunity. 16: 311-23. 10. Thaunat, O. et al. (2010) Immune responses elicited in tertiary lymphoid tissues display distinctive features.PLoS One. 5: e11398. 11. Wythe, S.E. et al. (2012) OX40 Ligand and Programmed Cell Death 1 Ligand 2 Expression on Inflammatory Dendritic Cells Regulates CD4 T Cell Cytokine Production in the Lung during Viral DiseaseJ Immunol. 188: 1647-55.2. Takeda, K. et al. (2000) CD27-mediated activation of murine NK cells. J. Immunol. 164: 1741 - 1745.
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