|Calculated MW||44956 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Recombinant extracellular domain of LT beta R.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Ltbr, Tnfcr, Tnfrsf3|
|Target/Specificity||Rat anti-Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes murine lymphotoxin-beta receptor (LT beta R), a member of the tumor necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Rat anti-Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes surface expressed LT beta R. Rat anti-Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (Hehlganset al.2003).Rat anti-Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is routinely tested on WEH1 cells.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse Lymphotoxin beta Receptor Antibody, clone 5G11b is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hehlgans, T. et al. (2003) Activation of the lymphotoxin - beta receptor induces NF Kappa B-dependent Interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells. Eur. Cytokine Netw. 14: 103 - 107. 2. Palumbo, M.O. et al. (2006) Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones.Diabetes. 55: 2595-601. 3. Moore, F. et al. (2007) An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha.J Immunol. 178: 1301-11. 4. Magari, M. et al. (2011) IL-21-Dependent B Cell Death Driven by Prostaglandin E2, a Product Secreted from Follicular Dendritic Cells.J Immunol. 187: 4210-8.1. Muller, P. et al. (2001) Functional characterization of the mouse lymphotoxin-beta receptor promoter. Eur. Cytokine Netw. 12: 325 - 330.
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