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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   Anti-Human CD200R Antibody, clone OX108 (RPE)   

Anti-Human CD200R Antibody, clone OX108

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human CD200R Antibody, clone OX108  ABD12222
    Staining of human peripheal blood monocytes with Mouse anti Human CD200R: Alexa Fluor® 647
  • IF - Anti-Human CD200R Antibody, clone OX108  ABD12222
    Published customer image:Mouse anti Human CD200R antibody, clone OX108 used for the identification of M2 macrophages in synovial tissue by immunofluorescence.Image caption:Double-immunofluorescence stainings of MΦIFN-γ, MΦIL-4, and MΦIL-10 polarization markers on synovial tissue from chronic inflammatory arthritis. Colocalization of MΦIFN-γ marker CD64 with CD200R (A), CD163 (B), and CD32 (C), colocalization of MΦIL-4 marker CD200R with CD14 (D), CD163 (E), and CD32 (F), and colocalization of MΦIL-10 marker CD163 with CD14 (G) and CD32 (H). Figure parts are representative of five spondyloarthritis and five rheumatoid arthritis patients.From: Ambarus CA, Noordenbos T, de Hair MJ, Tak PP, Baeten DL. Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.Arthritis Res Ther. 2012 Apr 11;14(2):R74.
  • FC - Anti-Human CD200R Antibody, clone OX108  ABD12222
    Staining of human peripheral blood lymphocytes probed with Mouse anti Human CD200R
  • IF - Anti-Human CD200R Antibody, clone OX108  ABD12222
    Published customer image:Mouse anti Human CD200R antibody, clone OX108 used for the identification of M2 macrophages in synovial tissue by immunofluorescence.Image caption:Double immunofluorescence stainings of CD68 and macrophage polarization markers on synovial tissue from chronic inflammatory arthritis. Colocalization of CD68 with MΦIFN-γ marker CD64 (A), MΦIL-4 markers CD200R (B) and CD14 (C), and MΦIL-10 markers CD163 (D), CD16 (E), and CD32 (F) on synovial tissue macrophages. Figures are representative of five spondyloarthritis and five rheumatoid arthritis patients. Higher-magnification photos are included in each figure part.From: Ambarus CA, Noordenbos T, de Hair MJ, Tak PP, Baeten DL. Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.Arthritis Res Ther. 2012 Apr 11;14(2):R74.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession Q8TD46
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names OX108
Calculated MW 36620 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Fusion protein hCD200RCD4d3+4.
Shelf Life 18 months from date of despatch.
Gene ID 131450
Other Names Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CD200R1, CD200R, CRTR2, MOX2R, OX2R
Target/Specificity Mouse anti-Human CD200R antibody, clone OX108 recognizes human CD200R, a cell surface glycoprotein (also known as OX2R). In humans CD200R is expressed primarily by peripheral blood monocytes and neutrophils but also by other leucocytes including T-lymphocytes and mast cells, CD200-CD200R interaction may be involved in the control of myeloid cellular function (Wrightet al.2003).Levels of expression on resting perispheral blood cells are relatively low.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD200R Antibody, clone OX108 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Wright, G.J. et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.
J Immunol. 171 (6): 3034-46. 2. Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions.
J Neuropathol Exp Neurol. 68: 159-67. 3. Melief, J. et al. (2013) Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed.
Glia. 61 (11): 1848-61. 4. Ambarus, C.A. et al. (2012) Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.
Arthritis Res Ther. 14 (2): R74. 5. Holmannova, D. et al. (2015) Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery.
Perfusion. 30 (7): 543-55. 6. Ambarus CA et al. (2012) Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.
PLoS One. 7 (4): e35994. 7. Memarian, A. et al. (2013) Upregulation of CD200 is associated with Foxp3+ regulatory T cell expansion and disease progression in acute myeloid leukemia.
Tumour Biol. 34 (1): 531-42. 8. Sousa, S. et al. (2015) Human breast cancer cells educate macrophages toward the M2 activation status.
Breast Cancer Res. 17 (1): 101. 9. Vicetti Miguel, R.D. et al. (2013) Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity.
PLoS One. 8 (3): e58565. 10. van de Garde, M.D. et al. (2014) Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.
J Immunol. 192 (3): 1196-208. 11. Melief, J. et al. (2012) Phenotyping primary human microglia: tight regulation of LPS responsiveness.
Glia. 60 (10): 1506-17.

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