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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse NKG2A/C/E Antibody, clone 20d5 (RPE)   

Anti-Mouse NKG2A/C/E Antibody, clone 20d5

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names 20d5
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen CHO transfected cells expressing the B6 allele of NKG2A.
Shelf Life 12 months from date of reconstitution.
Target/Specificity Rat anti-Mouse NKG2A/C/E monoclonal antibody, clone 20d5 recognizes murine NKG2A, NKG2C and NKG2E, which are isoforms of the NKG2 lectin-like family. In mice, NKG2 subunits associate with CD94 to form heterodimers at the surface of natural killer (NK) cells.The CD94/NKG2 heterodimer is the receptor for a non-classical MHC class I ligand, which is Qa-1 in the mouse (Colmeneroet al.2007).Rat anti-Mouse NKG2A/C/E, clone 20d5 is reported to block ligand binding to the receptor (Vanceet al.1999)
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse NKG2A/C/E Antibody, clone 20d5 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Vance, R.E. et al. (1999) Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.
J Exp Med. 190 (12): 1801-12. 2. Vance, R.E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
Proc Natl Acad Sci U S A. 99 (2): 868-73. 3. Kawamura, H. et al. (2005) Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.
Eur J Immunol. 35 (8): 2358-66. 4. Yin, Y. et al. (2013) Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation.
Cancer Immunol Res. 1 (4): 256-68. 5. Colmenero, P. et al. (2007) Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.
J Immunol. 179: 4608-15.

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Cat# ABD12225
(40 western blots)
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