|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||CHO transfected cells expressing the B6 allele of NKG2A.|
|Shelf Life||12 months from date of reconstitution.|
|Target/Specificity||Rat anti-Mouse NKG2A/C/E monoclonal antibody, clone 20d5 recognizes murine NKG2A, NKG2C and NKG2E, which are isoforms of the NKG2 lectin-like family. In mice, NKG2 subunits associate with CD94 to form heterodimers at the surface of natural killer (NK) cells.The CD94/NKG2 heterodimer is the receptor for a non-classical MHC class I ligand, which is Qa-1 in the mouse (Colmeneroet al.2007).Rat anti-Mouse NKG2A/C/E, clone 20d5 is reported to block ligand binding to the receptor (Vanceet al.1999)|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse NKG2A/C/E Antibody, clone 20d5 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Vance, R.E. et al. (1999) Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.J Exp Med. 190 (12): 1801-12. 2. Vance, R.E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.Proc Natl Acad Sci U S A. 99 (2): 868-73. 3. Kawamura, H. et al. (2005) Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells.Eur J Immunol. 35 (8): 2358-66. 4. Yin, Y. et al. (2013) Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation.Cancer Immunol Res. 1 (4): 256-68. 5. Colmenero, P. et al. (2007) Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.J Immunol. 179: 4608-15.
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