|Application ||IHC-F, FC|
|Clone Names||MVCAM A (429)|
|Calculated MW||81317 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||Stromal cell line PA6.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, CD106, Vcam1, Vcam-1|
|Target/Specificity||Rat anti-Mouse CD106 antibody, clone MVCAM A (429) recognizes murine vascular adhesion molecule 1 (VCAM-1), a cell surface glycoprotein that is also known as CD106. CD106 is expressed predominantly on endothelial cells and expression is up-regulated during inflammation. The ligand for CD106 is the alpha 4 subunit (CD49d) of the integrin VLA-4 (CD49d/CD29).Rat anti-Mouse CD106 antibody, clone MVCAM A (429) is reported to partially block VCAM-1 mediated functions (Kinashi and Springer 1994).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD106 Antibody, clone MVCAM A (429) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Kinashi, T. and Springer, T.A. (1994) Adhesion molecules in hematopoietic cells.Blood Cells. 20:25-44. 2. Wormley, F.L. Jr et al. (2001) Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis.Infect Immun. 69 (8): 5072-9. 3. Woo, J.M. et al. (2010) Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.Arthritis Res Ther. 12(3):R93. 4. Hall, L.J. et al. (2010) Probing local innate immune responses after mucosal immunisation.J Immune Based Ther Vaccines. 8: 5. 5. Winnik S et al. (2011) Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.Eur Heart J. 32 (20): 2573-84. 6. Hamada, T. et al. (2009) Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.Am J Pathol. 174: 2265-77. 7. Hamada, T. et al. (2008) Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury.Hepatology. 47: 186-98. 8. Baumer, Y. et al. (2011) Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells.Exp Biol Med (Maywood). 236: 692-700. 9. Lau,. H.Y. and Bhatia, M. (2007) Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice.Am J Physiol Gastrointest Liver Physiol. 292: G1283-92.
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