|Application ||FC, IP|
|Clone Names||HM beta 1-1|
|Calculated MW||88231 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Purified mouse VLA-4 antigen.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-1, Fibronectin receptor subunit beta, VLA-4 subunit beta, CD29, Itgb1|
|Target/Specificity||Hamster anti-Mouse CD29 antibody, clone HM beta 1-1 recognizes the murine integrin beta 1 subunit (CD29), a ~110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. CD29 forms non-covalent bonds with the integrin alpha subunits, including CD51 and CD49a-f, to form heterodimers. The ligands for these heterodimers include collagen, fibronectin, laminin and vascular adhesion molecule-1. In the immune system beta 1 integrins play an important role in cell adhesion, migration, activation and differentiation.Hamster anti-Mouse CD29 antibody, clone HM beta 1-1 is reported to inhibit beta 1 integrin mediated adhesion (Notoet al.1995).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD29 Antibody, clone HM beta 1-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb.Int Immunol. 7 (5): 835-42. 2. Lu, T.Y. et al. (2010) Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem. 285: 8719-32. 3. Li S et al. (2010) Upregulation of CXCR4 favoring neural-like cells migration via AKT activation.Neurosci Res. 67 (4): 293-9. 5. Eto, D.S. et al. (2007) Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.PLoS Pathog. 3: e100. 6. Tiede, B.J. et al. (2009) A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy.PLoS One. 4 (11): e8035. 7. Kouros-Mehr H (2008) GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.Cancer Cell. 13: 141-52.
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