|Application ||FC, IP|
|Clone Names||HM beta 3.1|
|Calculated MW||86738 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, Itgb3|
|Target/Specificity||Hamster anti-Mouse CD61 antibody, clone HM beta 3-1 recognizes the murine integrin beta 3 subunit (CD61), a 90kDa a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Hamster anti-Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin (Yasudaet al.1995).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD61 Antibody, clone HM beta 3.1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Yasuda, M. et al. (1995) Expression and function of fibronectin binding integrins on rat mast cells.Int. Immunol. 7:251-258. 2. Hodkinson, P.S. et al. (2007) Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.J Biol Chem. 282: 28991-9001. 3. Moore, S.F. et al. (2015) Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.Cardiovasc Res. 107 (1): 9-19.
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