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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human CD312 Antibody, clone 2A1 (RPE)   

Anti-Human CD312 Antibody, clone 2A1

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human CD312 Antibody, clone 2A1  ABD12244
    Staining of human peripheral blood granulocytes with Mouse anti Human CD312
  • FC - Anti-Human CD312 Antibody, clone 2A1  ABD12244
    Staining of human peripheral blood monocytes with Mouse anti Human CD312: FITC
  • FC - Anti-Human CD312 Antibody, clone 2A1  ABD12244
    Staining of human peripheral blood monocytes probed with Mouse anti Human CD312 : Alexa Fluor® 647
  • FC - Anti-Human CD312 Antibody, clone 2A1  ABD12244
    Staining of human peripheral blood monocytes with Mouse anti Human CD312: Biotin
  • FC - Anti-Human CD312 Antibody, clone 2A1  ABD12244
    Staining of human peripheral blood granulocytes with Mouse anti Human CD312: RPE
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-F, FC, IP
Primary Accession Q9UHX3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2A1
Calculated MW 90472 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen NIH-3T3 cells stably transfected with EMR2 (EGF1-5) cDNA
Shelf Life 18 months from date of despatch.
Gene ID 30817
Other Names EGF-like module-containing mucin-like hormone receptor-like 2, EGF-like module receptor 2, CD312, EMR2
Target/Specificity Mouse anti-Human CD312 antibody, clone 2A1 recognizes human EMR2, a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family of proteins, which is closely related to CD97. EMR2, also known as CD312, is predominantly expressed on myeloid dendritic cells, monocytes and tissue macrophages. Various isoforms of EMR2 have been documented. The ligand for the largest isoform of EMR2 has recently been identified as chrondroitin sulphate, which binds to the fourth EGF-like module of EMR2. Clone 2A1 specifically recognizes the stalk region of EMR2.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD312 Antibody, clone 2A1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Kwakkenbos. M.J. et al. (2002) The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.
J. Leukoc. Biol.71:854-862 2. Stacey. M. et al. (2003) The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chrondroitin sulphate glycosaminoglycans.
Blood.102:2916-2924 3. Yona, S. et al. (2008) Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function.
FASEB J. 22:741-51 4. Lin, H. et al. (2004) Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif.
J Biol Chem. 279:31823-321. Kwakkenbos. M.J. et al. (2004) The EGF-TM7 family: a postgenomic view.
Immunogenetics. 55:655-666

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Cat# ABD12244
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