|Application ||IHC-F, FC, IP|
|Calculated MW||32424 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||MTE1/MTE2 stromal cell lines.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Junctional adhesion molecule A, JAM-A, Junctional adhesion molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1|
|Target/Specificity||Rat anti-Mouse CD321 antibody, clone H202-106 recognizes murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD321 Antibody, clone H202-106 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Malergue, F.et al. (1998) A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets.Mol. Immunol.35:1111-1119 2. Prestwich, R.J. et al. (2009) Immune-mediated antitumor activity of reovirus is required for therapy and isindependent of direct viral oncolysis and replication. Clin Cancer Res. 15: 4374-81. 2. Aurrand-Lions, M. et al. (2001) Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members.Blood.98: 3699-3707. 3. Ebnett, K.et al. (2000) Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1.J. Biol. Chem.275: 27979-27988.
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