|Application ||FC, IP|
|Clone Names||TM-BETA 1|
|Calculated MW||60539 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Cells from murine IL-2RB+ transformant TART-mBeta.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, CD122, Il2rb|
|Target/Specificity||Rat anti-Mouse CD122 antibody, clone TM-BETA 1 recognizes the murine CD122 cell surface glycoprotein, a ~75-85 kDa molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse, CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets, monocytes and macrophages.CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells.Rat anti-Mouse CD122 antibody, clone TM-BETA 1 blocks IL-2 high affinity binding to the IL-2R beta receptor (Tanakaet al.1991).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD122 Antibody, clone TM-BETA 1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Tanaka, T. et al. (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.J Immunol. 147 (7): 2222-8. 2. Leung, K.T.
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