|Application ||WB, IHC-F, FC, IP|
|Calculated MW||201650 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||TSP-180 purified from Balb/c murine carcinoma.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-4, CD104, Itgb4|
|Target/Specificity||Rat anti-Mouse CD104 antibody, clone 346-11A recognizes mouse integrin beta 4 (CD104), a 200 kDa glycoprotein that can associate with integrin alpha 6 (CD49f) to form a heterodimer on the cell surface. Expression of CD104 is localised to the basal region of a wide variety of epithelial cells. In mice, CD104 is also expressed on peripheral neurones, carcinoma cell lines and a subset of endothelial cells. The alpha 6 beta 4 (CD49f/CD104) integrin has been identified as a component of hemidesmosomes in stratified squamous epithelium where it plays an important role in the adhesion of epithelia to basement membrane.Studies suggest that the CD49f/CD104 integrin is involved in cell matrix adhesion but expression of the CD49f/CD104 integrin in endothelial cells is thought to have a different function.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD104 Antibody, clone 346-11A is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Kennel, S.J. et al. (1992) The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice.J Cell Sci. 101 ( Pt 1): 145-50. 2. Kennel, S.J. et al. (1989) Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.J Biol Chem. 264 (26): 15515-21. 3. Moik, D.V. et al. (2011) Loss of migfilin expression has no overt consequences on murine development and homeostasis.J Cell Sci. 124: 414-21. 4. Lämmermann, T. et al. (2008) Rapid leukocyte migration by integrin-independent flowing and squeezing.Nature. 453: 51-5. 5. Sonnenberg, A. et al. (1990) The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties.J Cell Sci. 96:207-17. 6. Kennel, S.J. et al. (1986) Tumor antigen on benign adenomas and on murine lung carcinomas quantitated by a two-site monoclonal antibody assay.Cancer Res. 46:707-12.
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