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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse CD223 Antibody, clone C9B7W (RPE)   

Anti-Mouse CD223 Antibody, clone C9B7W

Rat Anti-Mouse Monoclonal Antibody

     
  • FC - Anti-Mouse CD223 Antibody, clone C9B7W  ABD12254
    Staining of CD223 transfected cells with Rat anti Mouse CD223
  • FC - Anti-Mouse CD223 Antibody, clone C9B7W  ABD12254
    Staining of CD223 transfected cells with Rat anti Mouse CD223:Alexa Fluor® 647
  • FC - Anti-Mouse CD223 Antibody, clone C9B7W  ABD12254
    Staining of CD223 transfected cells with Rat anti Mouse CD223:Alexa Fluor® 488
  • FC - Anti-Mouse CD223 Antibody, clone C9B7W  ABD12254
    Staining of CD223 transfected cells with Rat anti Mouse CD223
  • FC - Anti-Mouse CD223 Antibody, clone C9B7W  ABD12254
    Staining of CD223 transfected cells with Rat anti Mouse CD223:RPE
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession Q61790
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG1
Clone Names C9B7W
Calculated MW 56978 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Murine CD223 Ig fusion protein.
Shelf Life 12 months from date of reconstitution.
Gene ID 16768
Other Names Lymphocyte activation gene 3 protein, LAG-3, CD223, Lag3
Target/Specificity Rat anti-Mouse CD223 antibody, clone C9B7W recognizes murine lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. Rat anti-Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II (Workmanet al.2002).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Mouse CD223 Antibody, clone C9B7W is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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References

1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).
Eur J Immunol. 32 (8): 2255-63. 2. Workman, C.J. & Vignali, D.A. (2005) Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).
J Immunol. 174 (2): 688-95. 3. Byrne, K.T. et al. (2011) Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma.
J Clin Invest. 121 (5): 1797-809. 4. Workman, C.J. et al. (2002) Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.
J Immunol. 169 (10): 5392-5. 5. Hu, Z. et al. (2013) Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
J Immunol. 191 (1): 312-22. 6. Iwasaki, Y. et al. (2013) Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells.
Eur J Immunol. 43: 1063-73. 7. Ordway, D. et al. (2007) The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation.
J Immunol. 179: 522-31. 8. Woo, S.R. et al. (2010) Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4.
Eur J Immunol. 40: 1768-77.

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Cat# ABD12254
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