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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse CD301 Antibody, clone ER-MP23    

Anti-Mouse CD301 Antibody, clone ER-MP23

Rat Anti-Mouse Monoclonal Antibody

  • IHC - Anti-Mouse CD301 Antibody, clone ER-MP23  ABD12256
    Immunoperoxidase staining of a mouse lymph node with Rat anti Mouse CD301 antibody, clone ER-MP23 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . Low power
  • IHC - Anti-Mouse CD301 Antibody, clone ER-MP23  ABD12256
    Immunoperoxidase staining of a mouse lymph node with Rat anti Mouse CD301 antibody, clone ER-MP23 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . Medium power
  • IHC - Anti-Mouse CD301 Antibody, clone ER-MP23  ABD12256
    Immunoperoxidase staining of a mouse lymph node with Rat anti Mouse CD301 antibody, clone ER-MP23 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . High power
  • IF - Anti-Mouse CD301 Antibody, clone ER-MP23  ABD12256
    Published customer image:Rat anti Mouse CD301 antibody, clone ER-MP23 used for the detection of CD301 positive cells in murine atherosclerotic lesions by immunofluorescence.Image caption:Characterization of the M1 and M2 macrophage subsets in the vulnerable atherosclerotic lesion. (a) Double confocal immunofluorescence of atherosclerotic lesions showing CD68 and CD86 (M1 marker) on top or CD86 and CD301 (M2 marker) in the bottom. Arrows point double positive cells for CD68 and CD86 or CD301. (b) Quantification of lesional CD68-CD86 or CD68-CD301 area in the models (n=7-8; with 2-tailed t test). Cast HFD and LCCA LRA CD. LCCA: left common carotid artery; LRA: left renal artery; CD: chow diet; HFD: high fat diet.From: Citation: Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, et al. Atherosclerotic Plaque Destabilization in Mice: A Comparative Study.PLoS ONE 10: e0141019.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names ER-MP23
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Balb/c macrophage precursor cell hybrids.
Shelf Life 18 months from date of despatch.
Target/Specificity Rat anti-Mouse CD301 antibody, clone ER-MP23 recognizes murine CD301, a 38 kD cell surface protein that is otherwise known as macrophage galactose N-acetylgalactosamine lectin (MGL) or dendritic cell asialoglycoprotein (DC-ASGPR).In mice, CD301 is predominantly expressed on mature macrophages found associated with a wide range of connective tissues including macrophages in the dermis and the pancreas. Clone ER-MP23 also detects a population of dendritic cells in lymphoid tissue, which are probably recent immigrants from peripheral connective tissue sites. Expression of CD301 is induced by alternative (i.e. IL-4/IL-13 mediated) activation of macrophages and dendritic cells, but not all CD301 positive cells are necessarily IL-4/IL-13 stimulated.Clone ER-MP23 is reported to block the function of mouse CD301. The antibody binds both MGL1 and MGL2 homologues.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD301 Antibody, clone ER-MP23 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Leenen, P.J.M. et. al. (1994) Markers of mouse macrophage development detected by monoclonal antibodies.
J Immunol Methods. 174:5 – 19. 2. Geutskens, S.B. et al. (2005) Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
J Leukoc Biol. 78 (4): 845-52. 3. Abadie, V. et al. (2005) Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.
Blood. 106: 1843-50. 4. Dupasquier, M. et al. (2004) Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis.
J Invest Dermatol. 123: 876-9. 5. Sindrilaru, A. et al. (2011) An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
J Clin Invest. 121: 985-97. 6. Westcott, D.J. et al. (2009) MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity.
J Exp Med. 206: 3143-56. 7. Fischer-Posovszky, P. et al. (2011) Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated m2 macrophages.
Endocrinology. 152: 3074-81. 8. Spite, M. et al. (2011) Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity.
J Immunol. 187: 1942-9. 9. Raes, G. et al. (2005) Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.
J Leukoc Biol. 77: 321-7. 10. Freire, T. et al. (2010) Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant.
Blood. 116: 3526-36. 11. Lumeng, C.N. et al. (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.
Diabetes. 57: 3239-46. 12. Blyszczuk, P. et al. (2013) Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis.
Cardiovasc Res. 97 (2): 219-29. 13. Dib, L.H. et al. (2014) Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.
Endocrinology. 155: 40-6. 14. Ferret-Bernard, S. et al. (2012) Plasma membrane proteomes of differentially matured dendritic cells identified by LC-MS/MS combined with iTRAQ labelling.
J. Proteomics. 75: 938-48. 15. Orr, J.S. et al. (2012) Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages.
Diabetes. 61: 2718-27. 16. Wagner, M. et al. (2012) Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.
Angiogenesis.15: 481-95 17. Shah, R. et al. (2015) Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice.
PLoS One. 10 (9): e0138317. 18. Morris, M.E. et al. (2015) Systemically Delivered Adipose Stromal Vascular Fraction Cells Disseminate to Peripheral Artery Walls and Reduce Vasomotor Tone Through a CD11b+ Cell-Dependent Mechanism.
Stem Cells Transl Med. pii: sctm.2014-0252. 19. Vukman KV et al. (2013) Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction.
J Leukoc Biol. 94 (3): 439-48. 20. Hartwig, H. et al. (2015) Atherosclerotic Plaque Destabilization in Mice: A Comparative Study.
PLoS One. 10 (10): e0141019.

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Cat# ABD12256
(40 western blots)
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