|Application ||IHC-F, FC|
|Calculated MW||27149 Da|
|Purification||Ig fraction prepared by ammonium sulphate precipitation|
|Immunogen||Isolated C3H thymic stromal cells.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||CD209 antigen-like protein A, Dendritic cell-specific ICAM-3-grabbing non-integrin, DC-SIGN, CD209, Cd209a, Cire|
|Target/Specificity||Rat anti-Mouse Sign-R1 antibody, clone ER-TR9 recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human DC-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations.Like many C-type lectins, SIGN-R1 functions as a pathogen recognition receptor in vivo and plays an important role in defence against pathogens.Antibodies, produced by clone ER-TR9, are reported to block the uptake of neutral polysaccharides by macrophages (Kraalet al.1989).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse Sign-R1 Antibody, clone ER-TR9 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. van Vliet, E. et al. (1985) Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation.J Histochem Cytochem. 33 (1): 40-4. 2. Kraal, G. et al. (1989) Marginal zone macrophages and their role in the immune response against T-independent type 2 antigens: modulation of the cells with specific antibody.Eur J Immunol. 19 (4): 675-80. 3. Ravishankar, B. et al. (2012) Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.Proc Natl Acad Sci U S A. 109 (10): 3909-14. 4. Dupasquier, M. et al. (2004) Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis.J Invest Dermatol. 123: 876-9. 5. Geijtenbeek, T.B. et al. (2002) Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.Blood. 100: 2908-16. 6. Zhang, S.S. et al. (2008) Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination.J Biol Chem. 283: 31511-21. 7. Fukui, Y. et al. (2013) Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis.Br J Nutr. 110 (9): 1617-29. 8. van Bracht, E. et al. (2015) Biodistribution of size-selected lyophilisomes in mice.Eur J Pharm Biopharm. 94: 141-51. 9. Visvabharathy, L. et al. (2015) Propofol Increases Host Susceptibility to Microbial Infection by Reducing Subpopulations of Mature Immune Effector Cells at Sites of Infection.PLoS One. 10 (9): e0138043. 10. Ravishankar, B. et al. (2015) The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.Proc Natl Acad Sci U S A. 112 (34): 10774-9.1. Colton, C.A. (2009) Heterogeneity of microglial activation in the innate immune response in the brain.J Neuroimmune Pharmacol. 4 (4): 399-418.
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