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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse Sign-R1 Antibody, clone ER-TR9    

Anti-Mouse Sign-R1 Antibody, clone ER-TR9

Rat Anti-Mouse Monoclonal Antibody

  • IHC - Anti-Mouse Sign-R1 Antibody, clone ER-TR9  ABD12257
    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti MouseSIGN-R1 antibody, clone ER-TR9 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . Low power
  • IF - Anti-Mouse Sign-R1 Antibody, clone ER-TR9  ABD12257
    Published customer image:Rat anti Mouse SIGN-R1 antibody, clone ER-TR9 used for the evaluation of SIGN-R1 expression in murine spleen by immunofluorescence.Image caption:Propofol exposure leads to reduced numbers of marginal zone macrophages and T cell populations in the spleen, and facilitates dissemination of Lm into the white pulp. Mice were infected with 2 x 104 CFU Lm via intravenous tail vein inoculation in the absence or presence of propofol and sacrificed at 72 hours post-infection. Spleens were harvested, fixed, and antibody-stained for the marginal zone macrophage marker SIGN-RI as well as Lm (a) or for the pan-T cell marker CD3 (c). Images shown are all taken at a 10x magnification and are representative of 3 independent experiments. (b). Quantitation of marginal zone macrophages in the presence or absence of propofol in spleens of Lm-infected animals. Data is an average of 2–4 animals per treatment group, with counts taken from 5 fields per spleen section. Error bars indicate data ± SEM. * p
  • IHC - Anti-Mouse Sign-R1 Antibody, clone ER-TR9  ABD12257
    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti MouseSIGN-R1 antibody, clone ER-TR9 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . High power
  • IHC-P - Anti-Mouse Sign-R1 Antibody, clone ER-TR9  ABD12257
    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti MouseSIGN-R1 antibody, clone ER-TR9 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody . Medium power
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q91ZX1
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgM
Clone Names ER-TR9
Calculated MW 27149 Da
Additional Information
Purification Ig fraction prepared by ammonium sulphate precipitation
Immunogen Isolated C3H thymic stromal cells.
Shelf Life 12 months from date of reconstitution.
Gene ID 170786
Other Names CD209 antigen-like protein A, Dendritic cell-specific ICAM-3-grabbing non-integrin, DC-SIGN, CD209, Cd209a, Cire
Target/Specificity Rat anti-Mouse Sign-R1 antibody, clone ER-TR9 recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human DC-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations.Like many C-type lectins, SIGN-R1 functions as a pathogen recognition receptor in vivo and plays an important role in defence against pathogens.Antibodies, produced by clone ER-TR9, are reported to block the uptake of neutral polysaccharides by macrophages (Kraalet al.1989).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse Sign-R1 Antibody, clone ER-TR9 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. van Vliet, E. et al. (1985) Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation.
J Histochem Cytochem. 33 (1): 40-4. 2. Kraal, G. et al. (1989) Marginal zone macrophages and their role in the immune response against T-independent type 2 antigens: modulation of the cells with specific antibody.
Eur J Immunol. 19 (4): 675-80. 3. Ravishankar, B. et al. (2012) Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.
Proc Natl Acad Sci U S A. 109 (10): 3909-14. 4. Dupasquier, M. et al. (2004) Macrophages and dendritic cells constitute a major subpopulation of cells in the mouse dermis.
J Invest Dermatol. 123: 876-9. 5. Geijtenbeek, T.B. et al. (2002) Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.
Blood. 100: 2908-16. 6. Zhang, S.S. et al. (2008) Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination.
J Biol Chem. 283: 31511-21. 7. Fukui, Y. et al. (2013) Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis.
Br J Nutr. 110 (9): 1617-29. 8. van Bracht, E. et al. (2015) Biodistribution of size-selected lyophilisomes in mice.
Eur J Pharm Biopharm. 94: 141-51. 9. Visvabharathy, L. et al. (2015) Propofol Increases Host Susceptibility to Microbial Infection by Reducing Subpopulations of Mature Immune Effector Cells at Sites of Infection.
PLoS One. 10 (9): e0138043. 10. Ravishankar, B. et al. (2015) The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.
Proc Natl Acad Sci U S A. 112 (34): 10774-9.1. Colton, C.A. (2009) Heterogeneity of microglial activation in the innate immune response in the brain.
J Neuroimmune Pharmacol. 4 (4): 399-418.

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Cat# ABD12257
(40 western blots)
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