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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Mouse CD357 Antibody, clone YGITR765 (RPE)   

Anti-Mouse CD357 Antibody, clone YGITR765

Rat Anti-Mouse Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession O35714
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b
Clone Names YGITR765
Calculated MW 25334 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen NB2/6TG cells transfected with mouse CD357.
Shelf Life 18 months from date of despatch.
Gene ID 21936
Other Names Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr
Target/Specificity Rat anti-Mouse CD357 antibody, clone YGITR765 recognizes mouse CD357, also known as glucocorticoid-induced tumour necrosis factor receptor (mGITR) or Tnrfsf18, a member of the tumour necrosis superfamily. Mouse CD357 is predominantly expressed by CD4+/CD25+ T regulatory cells and on CD4+/CD25- cells upon activation.Mouse GITR ligand (mGITRL) can bind to CD357 and neutralise the suppressive effects of CD4+CD25+ regulatory T cells. CD357 signalling can also enhance the proliferation of naïve and primed T cells, suggesting a key role for CD357 in the regulation of T cell-mediated immunity (Chattopadhyayet al.2008).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD357 Antibody, clone YGITR765 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Cobbold, S.P. et al. (2004) Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
J Immunol. 172 (10): 6003-10. 2. Regateiro, F.S. et al. (2012) Foxp3 expression is required for the induction of therapeutic tissue tolerance.
J Immunol. 189 (8): 3947-56.

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Cat# ABD12263
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