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>   home   >   Products   >   Primary Antibodies   >   Anti-Bovine CD45RO Antibody, clone IL-A116 (RPE)   

Anti-Bovine CD45RO Antibody, clone IL-A116

Mouse Anti-Bovine Monoclonal Antibody

  • FC - Anti-Bovine CD45RO Antibody, clone IL-A116  ABD12269
    Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD45RO:RPE
  • FC - Anti-Bovine CD45RO Antibody, clone IL-A116  ABD12269
    Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD45RO followed by Goat anti Mouse IgG:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names IL-A116
Additional Information
Other Species Ga
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Bovine peripheral blood monouclear cells.
Shelf Life 12 months from date of reconstitution.
Target/Specificity Mouse anti-Bovine CD45RO, clone IL-A116, specifically recognises the bovine homologue of the human CD45RO cell surface antigen.CD45, also known as Leucocyte Common Antigen or LCA, occurs in a number of isoforms, clone IL-A116 is specific for the low molecular weight isoform termed CD45RO, the isoform associated with expression on memory T-cells. Bovine CD45RO is expressed by monocytes, granulocytes and subsets of thymocytes, CD4+ T cells and CD8+ T cells. Studies utilizing clone IL-A116 have demonstrated that the percentage of CD45RO+CD8+ T cells increase from approximately 5% in neonatal calves to approximately 35% in adult cattle over the age of 5 years (Hogget al.2011). It has been demonstrated that mouse anti-bovine CD45RO, clone IL-A116 immunoprecipitates a molecule of 180kDa (Bembridgeet al1995) which is analogus to the molecular weight of human and mouse CD45RO.Clone IL-A116 has been demonstrated to recognise the CD45RO cell surface antigen by flow cytometry in both European cattle, Bos taurus, and in Zebu, B.indicus(Bembridgeet al1995).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Bovine CD45RO Antibody, clone IL-A116 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Bembridge, al. (1995) CD45RO expression on bovine T cells: relation to biological function.
Immunology 86: 537-544. 2. Hogg A.E. et. al. (2011) Characterization of age-related changes in bovine CD8+ T-cells
Vet. Immunol. Immunopath. 140:47-54 3. Whelan A.O. et. al. (2011) Development of an Antibody to Bovine IL-2 Reveals Multifunctional CD4 TEM Cells in Cattle Naturally Infected with Bovine Tuberculosis
PLoS ONE 6(12): e29194. doi:10.1371/journal.pone.0029194 4. Howard, C.J. et al. (1993) Summary of workshop findings for cattle (Tables 1 and 2).
Vet Immunol. Immunopathol. 39:25-48. 5. Sopp, P. et al. (2001) IFN gamma and IL-4 production by CD4, CD8 and WC1 gamma delta TCR+ T cells from cattle lymph nodes and blood.
Vet. Immunol. Immunopathol. 81: 85-96. 6. McInnes, al. (1999) Phenotypic analysis of local cellular responses in calves infected with bovine respiratory syncytial virus.
Immunology 96: 396-403 7. Bembridge, G.P. et al. (1993) Comparison of monoclonal antibodies with potential specificity for restricted isoforms of the leukocyte common antigen (CD45R).
Vet. Immunol. Immunopathol. 39:129-136. 8. Naessens, J. et al. (1993) Cross-reactivity of workshop antibodies with cells from domestic and wild ruminants.
Vet. Immunol. Immunopathol. 39: 283-290.

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Cat# ABD12269
(40 western blots)
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