|Application ||IHC-F, FC|
|Calculated MW||39023 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||RBL-2H3 transfected cells expressing murine C5aR.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88, C5ar1, C5ar, C5r1|
|Target/Specificity||Rat anti-Mouse CD88 antibody, clone 10/92 recognizes murine CD88, a 45 kDa G-protein coupled cell surface receptor, otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, a potent proinflammatory molecule and chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes.Rat anti-Mouse CD88 antibody, clone 10/92 does not block the binding of the C5a to murine CD88 (Souriet al.2003).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD88 Antibody, clone 10/92 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Soruri, A. et al. (2003) Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody.Immunol Lett. 88:47-52. 2. Shagdarsuren, E. et al. (2010) C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice.Circulation. 122: 1026-36. 3. Manthey, H.D. et al. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.FASEB J. 25: 2447-55. 4. Cudaback, E. et al. (2011) Apolipoprotein E isoform-dependent microglia migration.FASEB J. 25: 2082-91. 5. Ager, R.R. et al. (2010) Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease.J. Neurochem. 113: 389-401 6. Brennan, F.H. et al. (2015) The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.J Neurosci. 35 (16): 6517-31. 7. Li, R. et al. (2013) C5L2: a controversial receptor of complement anaphylatoxin, C5a.FASEB J. 27 (3): 855-64.
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