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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Mouse CD88 Antibody, clone 10/92 (RPE)   

Anti-Mouse CD88 Antibody, clone 10/92

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD88 Antibody, clone 10/92  ABD12274
    Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88
  • FC - Anti-Mouse CD88 Antibody, clone 10/92  ABD12274
    Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88:Alexa Fluor® 488
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30993
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names 10/92
Calculated MW 39023 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen RBL-2H3 transfected cells expressing murine C5aR.
Shelf Life 18 months from date of despatch.
Gene ID 12273
Other Names C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88, C5ar1, C5ar, C5r1
Target/Specificity Rat anti-Mouse CD88 antibody, clone 10/92 recognizes murine CD88, a 45 kDa G-protein coupled cell surface receptor, otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, a potent proinflammatory molecule and chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes.Rat anti-Mouse CD88 antibody, clone 10/92 does not block the binding of the C5a to murine CD88 (Souriet al.2003).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD88 Antibody, clone 10/92 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Soruri, A. et al. (2003) Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody.
Immunol Lett. 88:47-52. 2. Shagdarsuren, E. et al. (2010) C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice.
Circulation. 122: 1026-36. 3. Manthey, H.D. et al. (2011) Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.
FASEB J. 25: 2447-55. 4. Cudaback, E. et al. (2011) Apolipoprotein E isoform-dependent microglia migration.
FASEB J. 25: 2082-91. 5. Ager, R.R. et al. (2010) Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease.
J. Neurochem. 113: 389-401 6. Brennan, F.H. et al. (2015) The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.
J Neurosci. 35 (16): 6517-31. 7. Li, R. et al. (2013) C5L2: a controversial receptor of complement anaphylatoxin, C5a.
FASEB J. 27 (3): 855-64.

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Cat# ABD12274
(40 western blots)
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