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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-Human CMKLR1 Antibody, clone BZ332 (FITC)   

Anti-Human CMKLR1 Antibody, clone BZ332

Rat Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99788
Reactivity Human
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names BZ332
Calculated MW 42322 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Peptide corresponding to an epitope within the N-terminal region of human CMKLR1.
Shelf Life 18 months from date of despatch.
Gene ID 1240
Other Names Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, CMKLR1, CHEMR23, DEZ
Target/Specificity Rat anti-Human CMKLR1 antibody, clone BZ332 recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC’s are recruited to sites of bleeding and tissue damage.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CMKLR1 Antibody, clone BZ332 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Zabel, B.A. et al. (2005) Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguishes plasmacytoid from myeloid dendritic cells in human blood.
J. Immunol. 174: 244 – 251. 2. Maheshwari, A. et al. (2009) Epithelial cells in fetal intestine produce chemerin to recruit macrophages.
Am J Physiol Gastrointest Liver Physiol. 297: G1-G10.

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Cat# ABD12279
(40 western blots)
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