|Calculated MW||42322 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Peptide corresponding to an epitope within the N-terminal region of human CMKLR1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, CMKLR1, CHEMR23, DEZ|
|Target/Specificity||Rat anti-Human CMKLR1 antibody, clone BZ332 recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC’s are recruited to sites of bleeding and tissue damage.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CMKLR1 Antibody, clone BZ332 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Zabel, B.A. et al. (2005) Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguishes plasmacytoid from myeloid dendritic cells in human blood.J. Immunol. 174: 244 – 251. 2. Maheshwari, A. et al. (2009) Epithelial cells in fetal intestine produce chemerin to recruit macrophages.Am J Physiol Gastrointest Liver Physiol. 297: G1-G10.
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