|Calculated MW||85659 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||26 amino acid peptide corresponding to residues 150-176 on human GCR linked to thyroglobulin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL|
|Target/Specificity||Mouse anti-Human Glucocorticoid Receptor antibody, clone 5E4 recognizes the human glucocorticoid receptor, also known as Nuclear receptor subfamily 3 group C member 1 (NR3C1), a 777 amino acid receptor bearing 3 distinct functional domains, an N-terminal modulating domain, a DNA binding domain and a C-terminal steroid binding domain. The human glucocorticoid receptor is located either in the cytoplasm of cells, prior to ligand binding associated with certain heat shock proteins (Kinoet al.2009), or the nucleus following binding to ligand (Werbet al.1978).Mutations in the glucocorticoid receptor gene can lead to familial glucocorticoid resistance, characterized by elevated plasma cortisol levels (Malchoffet al.1993).Mouse anti-human glucocorticoid receptor antibody, clone 5E4 has been demonstrated to cross-react with the murine glucocorticoid receptor (Bergquistet al.2014)|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Glucocorticoid Receptor Antibody, clone 5E4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Berki, T. et al. (1998) Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody.J. Immunol. Methods 214: 19-27. 2. Kim, S.Y. et al. (2010) Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell lineKorean J Pediatr 53: 753-8 3. Bergquist, M. et al. (2014) Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock.J Infect. pii: S0163-4453(14)00081-4.
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