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Anti-Mouse CD28 Antibody, clone E18 (RPE)

Mouse Anti-Mouse Monoclonal Antibody

     
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Product Information
Primary Accession P31041
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names E18
Calculated MW 25243 Da
Additional Information
Immunogen Alternate immunisation with A20 cells expressing mCD28 and recombinant mCD28Ig.
Gene ID 12487
Other Names T-cell-specific surface glycoprotein CD28, CD28, Cd28
Target/Specificity Mouse anti-Mouse CD28 antibody, clone E18 recognizes murine CD28, a co-stimulatory cell surface molecule expressed by T cell subsets. Clone E18 has been shown to be able to stimulate murine T lymphocytes in combination with anti-mouse CD3.
PrecautionsAnti-Mouse CD28 Antibody, clone E18 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Dennehy, K.M. et al. (2006) Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses.
J Immunol. 176 (10): 5725-9. 2. Beyersdorf, N. et al. (2008) Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody.
Blood. 112 (10): 4328-36. 3. Gogishvili, T. et al. (2012) Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.
J Allergy Clin Immunol. 130 (6): 1394-403.e4. 4. Pletinckx, K. et al. (2015) Immature dendritic cells convert anergic nonregulatory T cells into Foxp3- IL-10+ regulatory T cells by engaging CD28 and CTLA-4.
Eur J Immunol. 45 (2): 480-91.

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$ 541.00
Cat# ABD12282
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