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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD74 Antibody, clone Bu45 (FITC)   

Anti-Human CD74 Antibody, clone Bu45

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, IF, FC, IP, Func
Primary Accession P04233
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names Bu45
Calculated MW 33516 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen B lymphoblastoid cell line HFB1.
Shelf Life 18 months from date of despatch.
Gene ID 972
Other Names HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii, p33, CD74, CD74, DHLAG
Target/Specificity Mouse anti-Human CD74 antibody, clone Bu45 recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The Bu45 antibody recognizes 33, 35 and 41 kD isoforms of CD74. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes.CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. The Bu45 antibody binds to an epitope within the extracytoplasmic domain of the CD74 molecule, which is distal from the C-terminus.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD74 Antibody, clone Bu45 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Wraight, C.J. et al. (1990) Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
J Biol Chem.265:5787 – 5792. 2. Beswick, E.J. et al. (2005) Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production.
Infect Immun. 73: 2736-43. 3. Lapaque, N. et al. (2009) The HLA-DRalpha chain is modified by polyubiquitination.
J Biol Chem. 284: 7007-16. 4. van Bergen, J. et al. (1997) Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.
Proc Natl Acad Sci U S A. 94: 7499-502. 5. Barrera, C.A. et al. (2005) Polarized expression of CD74 by gastric epithelial cells.
J Histochem Cytochem. 53: 1481-9. 6. Beswick, E.J. et al. (2006) The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production.
Infect Immun. 74: 1148-55.

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Cat# ABD12288
(40 western blots)
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