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Anti-Human CD49d Antibody, clone Bu49

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13612
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names Bu49
Calculated MW 114900 Da
Additional Information
Other Species Dog
Purification Purified IgG prepared by affinity chromatography on Protein G.
Immunogen Hyatt myeloma cell line
Shelf Life 18 months from date of despatch.
Gene ID 3676
Other Names Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d, ITGA4, CD49D
Target/Specificity Mouse anti-Human CD49d monoclonal antibody, clone Bu49 recognizes human CD49d, also known as integrin alpha 4 or VLA-4 alpha subunit. CD49d is a 150kDa single pass type I transmembrane glycoprotein. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa (Hemleret al.1987). CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer’s patch high endothelial venules and postcapillary venules in lamina propria (Briskinet al.1997). CD49d is expressed on a broad range of cells including lymphocytes, monocytes, eosinophils and thymocytes. CD49d expression may serve as a prognostic parker of survival and disease progression in patients with chronic lymphocytic leukemia and may have therapeutic potential (Bulianet al.2008)Mouse anti-human CD49, clone Bu49 cross-reacts with the canine B-cell leukemia cell line GL-1 and induces homotypic cell aggregation (Ikewakiet al.2010)
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD49d Antibody, clone Bu49 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Oxford University Press. (1995) Leucocyte Typing V. White cell differentiation antigens.
Volume Two. p 1617 – 1618. 2. Ikewaki, N. et al. (2010) Anti-human very late antigen-alpha4 (CD49d) monoclonal antibody (BU49) cross-reacts with the canine B-cell leukemia cell line GL-1, resulting in the induction of homotypic cell aggregation.
Cell Immunol. 263: 55-64. 3. Hamilton, E. et al. (2012) Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.
Br J Haematol. 158: 589-99.

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Cat# ABD12289
(40 western blots)
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