|Application ||IHC-P, IHC-F, FC, IP|
|Calculated MW||81538 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44, LHR, MDU2, MDU3, MIC4|
|Target/Specificity||Mouse anti-Human CD44 antibody, clone Bu52 recognizes the human CD44 cell surface antigen, a 100kD glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and of the breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. The Bu52 antibody recognizes an epitope that is common to all CD44 isoforms. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD44 Antibody, clone Bu52 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Takahashi, K. et al. (1996) Keratan sulfate modification of CD44 modulates adhesion to hyaluronate.J Biol Chem.271: 9490 – 9496. 2. Belitsos, P.C. et al. (1990) Homotypic cell aggregation induced by anti-CD44 (Pgp-1) monoclonal antibodies and related to CD44(Pgp-1) expression. J. Immunol. 144: 1661 – 1670. 3. Katz E et al. (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer.Oncotarget. 3 (6): 608-19.
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