|Application ||IHC-F, FC, IP|
|Calculated MW||73302 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||MV4-11 acute monocyte leukaemia cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Choline transporter-like protein 1, CDw92, Solute carrier family 44 member 1, CD92, SLC44A1, CD92, CDW92, CTL1|
|Target/Specificity||Mouse anti-human CD92 antibody, clone VIM-15b recognizes the C-terminal variant of human CDw92 (isoform 3), also known as CTL1, a 70kDa multi-pass membrane protein, expressed by monocytes, neutrophils, certain myeloid and T cell lines, and weakly by endothelial cells, fibroblasts and epithelial cells.CDw92 is a member of the choline transporter-like protein family, so called due to their involvement in the efficient supply/transport of the natural amine choline, a vital cell nutrient required for the synthesis of cell membrane phospholipid components and the neurotransmitter acetylcholine.Clone VIM-15b is reported to augment the LPS-induced production of IL-10 by monocyte-derived dendritic cells (Mo-DCs), and the reduced expression of CDw92 by Mo-DCs treated with ionomycin or calcium ionophore, can be reinduced in the presence of IL-10 (Wille, S. et al.). Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD92 Antibody, clone VIM-15b is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Wille, S. et al. (2001) Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically in dendritic cells. J. Immunol. 167: 5795-5804. 2. Majdic, O. et al. (1995) Leucocyte Typing V. Oxford University Press, Oxford pp.984-985.1. O’Regan, S. et al. (2000) An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. P.N.A.S. 97: 1835-1840.
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