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>   home   >   Products   >   Primary Antibodies   >   Anti-Cat CD134 Antibody, clone 7D6 (FITC)   

Anti-Cat CD134 Antibody, clone 7D6

Mouse Anti-Cat Monoclonal Antibody

  • WB - Anti-Cat CD134 Antibody, clone 7D6  ABD12304
    Western Blot analysis of Feline CD134 wih clone 7D6 used at 1ug/ml lane 1 - Feline CD134 expressing cellslane 2 - Control cellslane 3 - Recombinant feline CD134-Fc fusion protein
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Cat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 7D6
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen CHO-derived feline CD134-Fc fusion protein.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Cat CD134 antibody, clone 7D6 recognizes feline CD134, otherwise known as OX40, a 43 kDa type I membrane protein and member of the tumor necrosis factor receptor superfamily, expressed predominantly by CD4+ activated T cells, and a key regulator of T cell-dependent immune responses.CD134 has been identified as the receptor for the OX40 ligand, CD252, expressed by activated B cells, acting as a co-stimulatory signal for the stimulation and secretion of immunoglobulins. CD134 has also been identified as a binding receptor for Feline Immunodeficiency Virus (FIV), acting along with CXC chemokine receptor 4 (CXCR4) to facilitate the entry of the virus into CD4+ primary target cells.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Cat CD134 Antibody, clone 7D6 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Willett, B.J. et al. (2007) Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (Ox40) ligand.
J Virol. 81: 9665-79. 2. Willett, B.J. et al. (2009) Enforced covalent trimerisation of soluble feline CD134 (OX40)-ligand generates a functional antagonist of feline immunodeficiency virus.
Mol Immunol. 46: 1020-30. 3. McDonnel, S.J. et al. (2012) Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes.
Virus Res. 170 (1-2): 174-9.1. Stüber, E. & Strober, W. (1996) The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.
J Exp Med. 183 (3): 979-89.2. de Parseval, A. et al. (2004) Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.
Proc Natl Acad Sci U S A. 101 (35): 13044-9.

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Cat# ABD12304
(40 western blots)
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