|Calculated MW||41913 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||25 amino acids from the amino terminal of murine CCR9, coupled to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, Chemokine C-C receptor 10, CDw199, Ccr9, Cmkbr10|
|Target/Specificity||Rat anti-Mouse CDw199 antibody, clone 9B1 detects mouse chemokine receptor 9 (CCR9), also known as CDw199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9. CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.Clone 9B1 blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CDw199 Antibody, clone 9B1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Rivera-Nieves, J. et al. (2006) Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology. 131: 1518-1529. 2. Nagakubo, D. et al. (2007) Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax. Int. J. Cancer. 120: 1591-15971. Uehara, S. et al. (2006) Premature expression of chemokine receptor CCR9 impairs T cell development. J. Immunol. 176: 75-84.
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