|Calculated MW||41913 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||25 amino acids from the amino terminal of murine CCR9, coupled to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, Chemokine C-C receptor 10, CDw199, Ccr9, Cmkbr10|
|Target/Specificity||Rat anti-Mouse CDw199 antibody, clone 9B1 detects mouse chemokine receptor 9 (CCR9), also known as CDw199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9. CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.Clone 9B1 blocks CCL25-induced Ca2+ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CDw199 Antibody, clone 9B1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Rivera-Nieves, J. et al. (2006) Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology. 131: 1518-1529. 2. Nagakubo, D. et al. (2007) Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax. Int. J. Cancer. 120: 1591-15971. Uehara, S. et al. (2006) Premature expression of chemokine receptor CCR9 impairs T cell development. J. Immunol. 176: 75-84.
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