|Application ||WB, IHC-P, IHC-F, FC|
|Calculated MW||87058 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||PHA stimulated peripheral blood cells.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A|
|Target/Specificity||Mouse anti-Human CD61 antibody, clone Y2/51 recognizes CD61, a ~105 kDa glycoprotein, also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51.CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD61 Antibody, clone Y2/51 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Phillips, D.R. et al. (1991) GPIIb-IIIa: the responsive integrin. Cell 65: 359-362. 2. Hynes, R.O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25. 3. Michelson, A. D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons. Leucocyte Typing V. Oxford University Press p 1230-1231. 4. Gatter, K. et al. (1998) The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology 13:257-267. 5. Kamat, V. et al. (2015) Microfluidic assessment of functional culture-derived platelets in human thrombi under flow.Exp Hematol. pii: S0301-472X(15)00510-X. 6. Ogino, T. et al. (2014) Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine.Free Radic Res. 48 (3): 292-302. 7. Tehrani, S. et al. (2010) Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia.Thromb Res. 126 (3): e225-31. 8. Dircks, B.H. et al. (2012) Platelet-neutrophil aggregate formation in blood samples from dogs with systemic inflammatory disorders.Am J Vet Res. 73 (7): 939-45. 9. Comazzi, S. et al. (2010) Acute megakaryoblastic leukemia in dogs: a report of three cases and review of the literature.J Am Anim Hosp Assoc. 46 (5): 327-35. 10. Kamat V et al. (2015) Microfluidic assessment of functional culture-derived platelets in human thrombi under flow.Exp Hematol. pii: S0301-472X(15)00510-X.
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