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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD274 Antibody, clone MIH2 (RPE)   

Anti-Human CD274 Antibody, clone MIH2

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human CD274 Antibody, clone MIH2  ABD12313
    Staining of human peripheral blood monocytes with Mouse anti Human CD274:Alexa Fluor® 647
  • FC - Anti-Human CD274 Antibody, clone MIH2  ABD12313
    Staining of human peripheral blood monocytes with Mouse anti Human CD274:Alexa Fluor® 488
  • FC - Anti-Human CD274 Antibody, clone MIH2  ABD12313
    Staining of human peripheral blood monocytes with Mouse anti Human CD274:FITC
  • FC - Anti-Human CD274 Antibody, clone MIH2  ABD12313
    Staining of human peripheral blood monocytes with Mouse anti Human CD274:RPE
  • FC - Anti-Human CD274 Antibody, clone MIH2  ABD12313
    Staining of human peripheral blood monocytes with Mouse anti Human CD274
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession Q9NZQ7
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIH2
Calculated MW 33275 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Human CD274 transfected P815 cells.
Shelf Life 18 months from date of despatch.
Gene ID 29126
Other Names Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Target/Specificity Mouse anti-Human CD274 antibody, clone MIH2 detects human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD274 Antibody, clone MIH2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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References

1. Kanai, T. et al. (2003) Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
J Immunol. 171 (8): 4156-63.

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Cat# ABD12313
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