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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD275 Antibody, clone MIH11 (FITC)   

Anti-Human CD275 Antibody, clone MIH11

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti-Human CD275 Antibody, clone MIH11  ABD12314
    Staining of human peripheral blood monocytes with Mouse anti Human CD275:FITC
  • FC - Anti-Human CD275 Antibody, clone MIH11  ABD12314
    Staining of human peripheral blood monocytes with Mouse anti Human CD275
  • FC - Anti-Human CD275 Antibody, clone MIH11  ABD12314
    Staining of human peripheral blood monocytes with Mouse anti Human CD275
  • FC - Anti-Human CD275 Antibody, clone MIH11  ABD12314
    Staining of human peripheral blood monocytes with Mouse anti Human CD275:Alexa Fluor® 488
  • FC - Anti-Human CD275 Antibody, clone MIH11  ABD12314
    Staining of human peripheral blood monocytes with Mouse anti Human CD275: RPE
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, FC
Primary Accession O75144
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIH11
Calculated MW 33349 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen CD275 - L cells.
Shelf Life 18 months from date of despatch.
Gene ID 102723996;23308
Other Names ICOS ligand, B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Target/Specificity Mouse anti-Human CD275 antibody, clone MIH11 detects CD275, also known as ICOS ligand (inducible T cell co-stimulator ligand). CD275 is a member of the B7 family, and interaction with its receptor CD278 (ICOS) plays an important role in T cell co-stimulation and inflammatory immune reactions. CD275 is expressed on activated B-cells, monocytes and dendritic cells and is also induced on non-lymphoid tissue cells such as endothelial cells, epithelial cells and muscle cells. CD275 has an important physiological role in the reactivation of effector/memory T cells on the endothelium, thus controlling entry of immune cells into inflamed tissue. The CD278-CD275 pathway is thought to be critical in the immune response to transplants, allergies and autoimmune diseases. MIH11 is reported to partially block the interaction between CD275 and CD278.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD275 Antibody, clone MIH11 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Youngnak-Piboonratanakit, P. et al. (2006) Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues.
Scand. J. Immunol. 63: 191-198.

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Cat# ABD12314
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