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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human B7-H4 Antibody, clone MIH43 (RPE)   

Anti-Human B7-H4 Antibody, clone MIH43

Mouse Anti-Human Monoclonal Antibody

  • IHC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Paraffin embedded breast carcinoma stained with Mouse anti Human B7-H4
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4 conjugated to Alexa Fluor® 647
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4:A488
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Staining of human peripheral blood monocytes with Mouse anti Human B7-H4:RPE
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z7D3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIH43
Calculated MW 30878 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Human B7-H4
Shelf Life 18 months from date of despatch.
Gene ID 79679
Other Names V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7-H4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Target/Specificity Mouse anti-Human B7-H4 antibody, clone MIH43 recognizes human B7-H4, also known as B7x, a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response.B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human B7-H4 Antibody, clone MIH43 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. van de Ven, R. et al. (2011) Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.
Blood. 118: 2502-10.

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Cat# ABD12316
(40 western blots)
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