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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human B7-H4 Antibody, clone MIH43 (RPE)   

Anti-Human B7-H4 Antibody, clone MIH43

Mouse Anti-Human Monoclonal Antibody

     
  • IHC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Paraffin embedded breast carcinoma stained with Mouse anti Human B7-H4
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4 conjugated to Alexa Fluor® 647
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4:A488
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Staining of human peripheral blood monocytes with Mouse anti Human B7-H4:RPE
  • FC - Anti-Human B7-H4 Antibody, clone MIH43  ABD12316
    Peripheral Human Monocytes stained with Mouse anti Human B7-H4:FITC
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IHC-F, FC
Primary Accession Q7Z7D3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIH43
Calculated MW 30878 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Human B7-H4
Shelf Life 18 months from date of despatch.
Gene ID 79679
Other Names V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7-H4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 {ECO:0000312|EMBL:EAW56672.1}
Target/Specificity Mouse anti-Human B7-H4 antibody, clone MIH43 recognizes human B7-H4, also known as B7x, a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response.B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human B7-H4 Antibody, clone MIH43 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. van de Ven, R. et al. (2011) Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.
Blood. 118: 2502-10.

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Cat# ABD12316
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