|Application ||FC, IP|
|Calculated MW||59541 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3|
|Target/Specificity||Mouse anti-Human CD50 antibody, clone Bu65 recognizes human CD50, also known as Inter-cellular adhesion molecule-3 (ICAM-3). CD50 is an 110kD type I transmembrane glycoprotein which is expressed mainly on resting leukocytes. It interacts with lymphocyte function-associated antigen-1 (LFA-1) and DC-SIGN, and is involved in the intercellular adhesion of leukocytes and augments CD3 signalling in T-lymphocyte activation. CD50 expression induces cancer cell proliferation and over-expression may contribute to cancer progression. It has also been implicated in limiting HIV-1 replication.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD50 Antibody, clone Bu65 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Garland Publishing, Inc. (1998) .Leucocyte Typing VI. 403–409.1. Biggins, J.E. et al. (2007) ICAM-3 influences human immunodeficiency virus type 1 replication in CD4(+) T cells independent of DC-SIGN-mediated transmission. Virology. 364: 383-394. 2. Berney, S.M. et al. (1999) ICAM-3 (CD50) cross-linking augments signaling in CD3-activated peripheral human T lymphocytes. J. Leukoc. Biol. 65: 867-874.3. Kim, Y.G. et al. (2006) ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway. Cancer Lett. 239: 103-110.
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