|Application ||WB, IHC-F, FC, E, Func|
|Calculated MW||87528 Da|
|Purification||Antisera to human CD144 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant protein fragments corresponding to amino acids 1-258 of VE-cadherin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5|
|Target/Specificity||Rabbit anti-Human CD144 antibody recognizes human CD144, also known as VE-cadherin. CD144 is a ~130 KDa cell surface glycoprotein expressed by endothelial cells. Rabbit anti-Human CD144 antibody does not cross react with N-cadherin, which is also expressed by endothelial cells. Rabbit anti-Human CD144 antibody is reported to block adhesive properties of VE-cadherin (Gulino, D. et al.1998).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Human CD144 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Gulino, D. et al. (1998) Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin. J. Biol. Chem. 273: 29786 - 29793. 2. Koga, H. (2005) Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease.J Am Coll Cardiol. 45:1622-30. 3. Rigolin, G.M. et al. (2010) Circulating endothelial cells in patients with chronic lymphocytic leukemia: clinical-prognostic and biologic significance.Cancer. 116:1926-37 4. Machalinska, A. et al. (2011) Different populations of circulating endothelial cells in patients with age-related macular degeneration: a novel insight into pathogenesis.Invest Ophthalmol Vis Sci. 52 (1): 93-100. 5. Kuczmarski, J.M. et al. (2011) Effect of moderate-to-severe chronic kidney disease on flow-mediated dilation and progenitor cells.Exp Biol Med (Maywood). 236 (9): 1085-92. 6. Glading, A. et al. (2007) KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.J Cell Biol. 179: 247-54. 7. Kumorek, M. et al. (2015) Cellular Responses Modulated by FGF-2 Adsorbed on Albumin/Heparin Layer-by-Layer Assemblies.PLoS One. 10 (5): e0125484.
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